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    bru3 bruno 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bru3provided by FlyBase
    Official Full Name
    bruno 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0264001
    Locus tag
    Dmel_CG43744
    See related
    AllianceGenome:FB:FBgn0264001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bru-3; Bru-3; BRU-3; bruno-3; cg10046; CG10046; cg12478; CG12478; CG34243; CG43744; Dm Bru-3; Dmel\CG43744; l(3)05871
    Old locus tag
    Dmel_CG12478; Dmel_CG34243
    Summary
    Enables RNA binding activity and protein homodimerization activity. Predicted to be involved in mRNA splice site recognition; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Part of protein-containing complex. Is expressed in several structures, including central brain primordium; dorsal sensory complex proper primordium; embryonic head epidermis; ganglia; and sense organ. Used to study dilated cardiomyopathy and myotonic dystrophy type 1. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bru3 in Genome Data Viewer
    Location:
    70B4-70C4; 3-41 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13521907..13803400, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13515007..13796500, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Liprin-beta Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45825 Neighboring gene Vacuolar protein sorting 36 Neighboring gene long non-coding RNA:CR45178 Neighboring gene long non-coding RNA:CR45120 Neighboring gene mir-289 stem loop Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cytoplasmic Bru-3 contributes to myotonic dystrophy type 1 pathogenesis in a Drosophila model by regulating sarcomeric transcripts and protein levels.
      Title: Bruno-3 regulates sarcomere component expression and contributes to muscle phenotypes of myotonic dystrophy type 1.
    2. Drosophila Bruno paralogue, the 45 kDa Bru-3 protein (p45), binds specifically to the EDEN element and acts as a homodimer
      Title: The Drosophila Bruno paralogue Bru-3 specifically binds the EDEN translational repression element.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of translation ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bruno 3
    Names
    CG43744-PA
    CG43744-PB
    CG43744-PC
    CG43744-PD
    CG43744-PE
    CG43744-PF
    CG43744-PG
    CG43744-PH
    CG43744-PI
    CG43744-PJ
    CG43744-PK
    CG43744-PL
    CG43744-PM
    CG43744-PN
    CG43744-PO
    CG43744-PP
    CG43744-PQ
    CG43744-PR
    bru3-PA
    bru3-PB
    bru3-PC
    bru3-PD
    bru3-PE
    bru3-PF
    bru3-PG
    bru3-PH
    bru3-PI
    bru3-PJ
    bru3-PK
    bru3-PL
    bru3-PM
    bru3-PN
    bru3-PO
    bru3-PP
    bru3-PQ
    bru3-PR
    bruno-3
    bruno3
    lethal (3) 05871

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13521907..13803400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202166.4 → NP_001189095.1  bruno 3, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189095.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6K8, M9MS36
      Conserved Domains (3) summary
      cd12639
      Location:327 → 405
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:43 → 412
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    2. NM_001202171.2 → NP_001189100.1  bruno 3, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189100.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L6, M9MS39
      Conserved Domains (3) summary
      TIGR01628
      Location:31 → 165
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12639
      Location:281 → 359
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:27 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001202163.2 → NP_001189092.1  bruno 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L0, M9MRU5
      Conserved Domains (3) summary
      cd12639
      Location:319 → 397
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:43 → 404
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    4. NM_001202165.2 → NP_001189094.1  bruno 3, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189094.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L1, M9MRT4
      Conserved Domains (3) summary
      cd12639
      Location:301 → 379
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:40 → 386
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    5. NM_001202167.2 → NP_001189096.1  bruno 3, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189096.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L1, D1L6L3, M9MRZ5
      Conserved Domains (3) summary
      cd12639
      Location:295 → 373
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:17 → 380
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:34 → 114
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    6. NM_001274879.1 → NP_001261808.1  bruno 3, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L0, M9PI52
      Conserved Domains (3) summary
      cd12635
      Location:35 → 115
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:314 → 392
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:38 → 399
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    7. NM_001382117.1 → NP_001369051.1  bruno 3, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7V1, D1L6L0
      Conserved Domains (4) summary
      cd12639
      Location:346 → 424
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:70 → 431
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:67 → 147
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl17169
      Location:12 → 58
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001274878.1 → NP_001261807.1  bruno 3, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261807.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L0, M9PI52
      Conserved Domains (3) summary
      cd12635
      Location:35 → 115
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:314 → 392
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:38 → 399
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    9. NM_001202169.2 → NP_001189098.1  bruno 3, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6M0, M9MSL2
      Conserved Domains (3) summary
      cd12639
      Location:242 → 320
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:37 → 327
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:27 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. NM_001202164.2 → NP_001189093.1  bruno 3, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L8, M9MSL1
      Conserved Domains (3) summary
      cd12639
      Location:248 → 326
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:140 → 333
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:27 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_079335.6 → NP_524059.4  bruno 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524059.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L6, Q9VU90
      Related
      FBpp0303379
      Conserved Domains (3) summary
      cd12639
      Location:274 → 352
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:140 → 359
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:27 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. NM_001202170.2 → NP_001189099.1  bruno 3, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189099.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L7, M9MRT9
      Conserved Domains (4) summary
      TIGR01628
      Location:31 → 173
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12639
      Location:256 → 334
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:148 → 341
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cl17169
      Location:27 → 75
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. NM_001202162.2 → NP_001189091.1  bruno 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189091.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L5, M9MRZ0
      Conserved Domains (3) summary
      cd12639
      Location:293 → 371
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:40 → 378
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    14. NM_001382115.1 → NP_001369049.1  bruno 3, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L0, M9MRU5
      Conserved Domains (3) summary
      cd12639
      Location:319 → 397
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:43 → 404
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    15. NM_001382116.1 → NP_001369050.1  bruno 3, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q6L8
      Conserved Domains (3) summary
      cd12639
      Location:319 → 397
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:43 → 404
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:40 → 120
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    16. NM_001202168.2 → NP_001189097.1  bruno 3, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MRV0

    17. NM_001202161.2 → NP_001189090.1  bruno 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L5, M9MS33
      Conserved Domains (3) summary
      cd12639
      Location:307 → 385
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:32 → 392
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:54 → 134
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    18. NM_168557.3 → NP_729923.1  bruno 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729923.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1L6L0, Q95T02, Q9VU91
      Related
      FBpp0303375
      Conserved Domains (3) summary
      cd12639
      Location:333 → 411
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:57 → 418
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:54 → 134
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A6M3Q6L8 A0A6M3Q6L8
    A0A6M3Q7V1 A0A6M3Q7V1
    M9MRT4 M9MRT4
    M9MRT9 M9MRT9
    M9MRU5 M9MRU5
    M9MRV0 M9MRV0
    M9MRZ0 M9MRZ0
    M9MRZ5 M9MRZ5
    M9MS33 M9MS33
    M9MS36 M9MS36
    M9MS39 M9MS39
    M9MSL1 M9MSL1
    M9MSL2 M9MSL2
    M9PI52 M9PI52
    Q9VU90 Q9VU90
    Q9VU91 Q9VU91

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