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    Reck Reversion-inducing-cysteine-rich protein with kazal motifs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Reckprovided by FlyBase
    Official Full Name
    Reversion-inducing-cysteine-rich protein with kazal motifsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036463
    Locus tag
    Dmel_CG5392
    See related
    AllianceGenome:FB:FBgn0036463
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5392; Dmel\CG5392; RECK
    Summary
    Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in extracellular matrix organization and regulation of canonical Wnt signaling pathway. Predicted to be active in plasma membrane. Orthologous to human RECK (reversion inducing cysteine rich protein with kazal motifs). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Reck in Genome Data Viewer
    Location:
    71B1-71B1; 3-42 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15001238..15014062, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14994338..15007162, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene minidiscs Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene Proteasome beta2 subunit Neighboring gene mitochondrial ribosomal protein L39 Neighboring gene Synaptotagmin beta Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 12-related

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion. Srivastava A, et al. Proc Natl Acad Sci U S A, 2007 Feb 20. PMID 17301221, Free PMC Article
    2. RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. Siekhaus D, et al. Nat Cell Biol, 2010 Jun. PMID 20495554, Free PMC Article
    3. The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling. Külshammer E, et al. J Cell Sci, 2013 Feb 15. PMID 23239028
    4. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. Pézeron G, et al. J Cell Sci, 2014 Nov 1. PMID 25217625, Free PMC Article
    5. Genome-wide assessment of AU-rich elements by the AREScore algorithm. Spasic M, et al. PLoS Genet, 2012 Jan. PMID 22242014, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitor
      Title: Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Reversion-inducing-cysteine-rich protein with kazal motifs
    Names
    CG5392-PA
    CG5392-PB
    Reck-PA
    Reck-PB
    reversion-inducing-cysteine-rich protein with kazal motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15001238..15014062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274924.1 → NP_001261853.1  Reversion-inducing-cysteine-rich protein with kazal motifs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B5, Q9VUJ2
      Conserved Domains (1) summary
      cd00104
      Location:729 → 753
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

    2. NM_140476.3 → NP_648733.2  Reversion-inducing-cysteine-rich protein with kazal motifs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648733.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960B5, Q9VUJ2
      Related
      FBpp0075424
      Conserved Domains (1) summary
      cd00104
      Location:729 → 753
      KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960B5 Q960B5
    Q9VUJ2 Q9VUJ2

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