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    mRpL40 mitochondrial ribosomal protein L40 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41364, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mRpL40provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein L40provided by FlyBase
    Primary source
    FLYBASE:FBgn0037892
    Locus tag
    Dmel_CG5242
    See related
    AllianceGenome:FB:FBgn0037892
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5242; Dmel\CG5242; MRPL22(24); mRpL22-24
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrial ribosome. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; embryonic/larval midgut; embryonic/larval midgut primordium; and gastric caecum. Used to study DiGeorge syndrome. Orthologous to human MRPL40 (mitochondrial ribosomal protein L40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpL40 in Genome Data Viewer
    Location:
    86E4-86E4; 3-51 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11407918..11408756)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7233640..7234478)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene prospero Neighboring gene long non-coding RNA:CR46009 Neighboring gene long non-coding RNA:CR46010 Neighboring gene ncRNA Neighboring gene merry-go-round Neighboring gene Inverted repeat-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus. Gokhale A, et al. J Neurosci, 2021 Aug 4. PMID 34261699, Free PMC Article
    2. dKDM5/LID regulates H3K4me3 dynamics at the transcription-start site (TSS) of actively transcribed developmental genes. Lloret-Llinares M, et al. Nucleic Acids Res, 2012 Oct. PMID 22904080, Free PMC Article
    3. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
    4. Mitochondrial Neurodegeneration: Lessons from Drosophila melanogaster Models. Brischigliaro M, et al. Biomolecules, 2023 Feb 16. PMID 36830747, Free PMC Article
    5. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrial ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein L40
    Names
    CG5242-PA
    mRpL40-PA
    mitochondrial ribosomal protein L22/24

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11407918..11408756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079594.5 → NP_524318.1  mitochondrial ribosomal protein L40 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGP7
      Related
      FBpp0081860
      Conserved Domains (1) summary
      pfam09812
      Location:33 → 177
      MRP-L28; Mitochondrial ribosomal protein L28
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGP7 Q9VGP7

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