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    CG32473 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41636, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG32473provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052473
    Locus tag
    Dmel_CG32473
    See related
    AllianceGenome:FB:FBgn0052473
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11688; CG8775; Dmel\CG32473; GM08240p
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic anal pad; epithelium; germline cell; and gut section. Orthologous to human ENPEP (glutamyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32473 in Genome Data Viewer
    Location:
    87E5-87E5; 3-53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13302648..13312785)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9128370..9138507)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome. Rach EA, et al. Genome Biol, 2009. PMID 19589141, Free PMC Article
    2. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article
    3. Zn2+-induced reversible dissociation of subunit Rpn10/p54 of the Drosophila 26 S proteasome. Kiss P, et al. Biochem J, 2005 Oct 15. PMID 15946124, Free PMC Article
    4. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
    5. Proteomic analysis reveals CCT is a target of Fragile X mental retardation protein regulation in Drosophila. Monzo K, et al. Dev Biol, 2010 Apr 15. PMID 20122915, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32473-PA
    CG32473-PB
    CG32473-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13302648..13312785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169503.3 → NP_731786.1  uncharacterized protein Dmel_CG32473, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5RJT1, Q9VFW7
      Related
      FBpp0082210
      Conserved Domains (3) summary
      cd09601
      Location:143 → 589
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:135 → 524
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:664 → 979
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_169504.3 → NP_731787.1  uncharacterized protein Dmel_CG32473, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731787.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAE2, Q8INH6
      Related
      FBpp0082211
      Conserved Domains (3) summary
      cd09601
      Location:151 → 602
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:143 → 537
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:677 → 992
      ERAP1_C; ERAP1-like C-terminal domain

    3. NM_142019.3 → NP_650276.2  uncharacterized protein Dmel_CG32473, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650276.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE8, Q8INH5
      Related
      FBpp0082212
      Conserved Domains (3) summary
      cd09601
      Location:29 → 480
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:21 → 415
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:555 → 870
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P55 Q86P55
    Q8IGR1 Q8IGR1
    Q8INH5 Q8INH5
    Q8INH6 Q8INH6
    Q95S62 Q95S62
    Q9VFW7 Q9VFW7

    Gene LinkOut

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