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    kmr kramer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kmrprovided by FlyBase
    Official Full Name
    kramerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085412
    Locus tag
    Dmel_CG34383
    See related
    AllianceGenome:FB:FBgn0085412
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14365; CG14366; CG34383; CG9322; Dmel\CG34383; Dm_3R:52023; PLEKHA4
    Old locus tag
    CG14365; CG14366; CG9322; Dmel_CG14365; Dmel_CG14366; Dmel_CG9322
    Summary
    Predicted to enable phosphatidylinositol bisphosphate binding activity. Involved in regulation of establishment of planar polarity. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including dorsal ectoderm; dorsal ectoderm anlage; epithelium; gut section; and mesoderm. Orthologous to several human genes including PLEKHA4 (pleckstrin homology domain containing A4); PLEKHA5 (pleckstrin homology domain containing A5); and PLEKHA6 (pleckstrin homology domain containing A6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kmr in Genome Data Viewer
    Location:
    87F12-87F13; 3-54 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13715207..13764667)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9540929..9590389)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR34044 Neighboring gene primo-1 Neighboring gene primo-2 Neighboring gene Ubiquitin conjugating enzyme 87F Neighboring gene uncharacterized protein Neighboring gene Chitinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of Trpm activation and calcium wave initiation during Drosophila egg activation. Hu Q, et al. Mol Reprod Dev, 2020 Aug. PMID 32735035, Free PMC Article
    2. Wnt/β-catenin signaling within multiple cell types dependent upon kramer regulates Drosophila intestinal stem cell proliferation. Sun H, et al. iScience, 2024 Jun 21. PMID 38952681, Free PMC Article
    3. Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins. Harrison C, et al. Biochem Soc Trans, 2020 Aug 28. PMID 32820799, Free PMC Article
    4. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
    5. Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo. Deignan L, et al. PLoS Genet, 2016 Jul. PMID 27379389, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling.
      Title: PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of establishment of planar polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extrinsic component of cytoplasmic side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kramer
    Names
    CG34383-PB
    CG34383-PD
    CG34383-PE
    CG34383-PF
    CG34383-PG
    CG34383-PH
    CG34383-PI
    CG34383-PJ
    CG34383-PK
    CG34383-PL
    kmr-PB
    kmr-PD
    kmr-PE
    kmr-PF
    kmr-PG
    kmr-PH
    kmr-PI
    kmr-PJ
    kmr-PK
    kmr-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13715207..13764667
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142053.2 → NP_650310.2  kramer, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650310.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHA9
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    2. NM_001275622.1 → NP_001262551.1  kramer, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR02
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    3. NM_001104308.3 → NP_001097778.1  kramer, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097778.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR00
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    4. NM_001275620.1 → NP_001262549.1  kramer, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR03
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    5. NM_001104306.3 → NP_001097776.1  kramer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR03
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    6. NM_001104305.3 → NP_001097775.2  kramer, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097775.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR01
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    7. NM_001104307.3 → NP_001097777.1  kramer, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR02
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    8. NM_001144575.2 → NP_001138047.1  kramer, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JR02
      Conserved Domains (2) summary
      cd13248
      Location:366 → 469
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:372 → 469
      PH; PH domain

    9. NM_001275619.2 → NP_001262548.1  kramer, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH30
      Conserved Domains (2) summary
      cd13248
      Location:388 → 491
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:394 → 491
      PH; PH domain

    10. NM_001275623.1 → NP_001262552.1  kramer, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262552.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGM4
      Conserved Domains (2) summary
      cd13248
      Location:388 → 491
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:394 → 491
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGM4 A0A0B4KGM4
    A0A0B4KH30 A0A0B4KH30
    A0A0C4DHA9 A0A0C4DHA9
    A8JR00 A8JR00
    A8JR01 A8JR01
    A8JR02 A8JR02
    A8JR03 A8JR03

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