Ada2a transcriptional Adaptor 2a [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ada2aprovided by FlyBase
Official Full Name: transcriptional Adaptor 2aprovided by FlyBase
Primary source: FLYBASE:FBgn0263738
Locus tag: Dmel_CG43663
See related: AllianceGenome:FB:FBgn0263738
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ada2a; Ada2A; ADA2a; CG31318; CG33520; CG43663; CG7150; dAda2a; dAda2A; dADA2a; DmAda2a; DmADA2a; Dmel\CG43663
Summary: Predicted to enable chromatin binding activity and transcription coactivator activity. Involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Located in euchromatin and nucleus. Part of ATAC complex. Is expressed in embryonic brain; embryonic hindgut; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to human TADA2A (transcriptional adaptor 2A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 90F10-90F11; 3-62 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18252843..18255487, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (14078565..14081209, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADA2 C-terminal regions play an important role in the specific incorporation of ADA2 into SAGA- or ATAC-type complexes, which in turn determines H3- or H4-specific histone targeting.
Title: The C-terminal domains of ADA2 proteins determine selective incorporation into GCN5-containing complexes that target histone H3 or H4 for acetylation.
This study reports the transcriptome analysis of Drosophila melanogaster dAda2a and dAda3 mutants, in which subunits of the ATAC acetyltransferase complex are affected.
Title: Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila.
there is no tight functional link between DmADA2a and DmRPB4.
Title: The dissociable RPB4 subunit of RNA Pol II has vital functions in Drosophila.
Involved in both uniformly distributed histone H4 acetylation and gene-specific transcription regulation.
Title: The Drosophila histone acetyltransferase Gcn5 and transcriptional adaptor Ada2a are involved in nucleosomal histone H4 acetylation.
The ADA2a gene, functionally distinct homolog of ADA2b, is essential for the Drosophila development.
Title: The homologous Drosophila transcriptional adaptors ADA2a and ADA2b are both required for normal development but have different functions.
in vivo the two dADA2 proteins showed different localizations on polytene X chromosomes. These results, taken together, suggest that the two Drosophila ADA2 homologues are present in distinct GCN5-containing HAT complexes
Title: Two different Drosophila ADA2 homologues are present in distinct GCN5 histone acetyltransferase-containing complexes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

transcript and protein products are distinct from overlapping gene

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of SAGA-type complex	IBA Inferred from Biological aspect of Ancestor more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcriptional adaptor 2a

Names: Ada2a-PA; Ada2a-PB; Ada2a-PC; Ada2a-PE; Ada2a-PG; CG43663-PA; CG43663-PB; CG43663-PC; CG43663-PE; CG43663-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

18252843..18255487 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001014637.3 → NP_001014637.1 transcriptional adaptor 2a, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014637.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIP2

Conserved Domains (4) summary

COG5114
Location:81 → 523

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:139 → 180

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:80 → 126

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:453 → 520

SWIRM; SWIRM domain
NM_001014635.3 → NP_001014635.1 transcriptional adaptor 2a, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014635.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KSD8

Conserved Domains (4) summary

COG5114
Location:81 → 543

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:139 → 180

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:80 → 126

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:473 → 540

SWIRM; SWIRM domain
NM_001014634.3 → NP_001014634.1 transcriptional adaptor 2a, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014634.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KSD8

Conserved Domains (4) summary

COG5114
Location:96 → 538

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:154 → 195

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:95 → 141

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:468 → 535

SWIRM; SWIRM domain
NM_001014636.3 → NP_001014636.1 transcriptional adaptor 2a, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014636.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q4V6Z0, Q59DW3, Q59DW4, Q7KSD8, Q8I8U8, Q8I9F2, Q8I9F3, Q8IN85

Conserved Domains (4) summary

COG5114
Location:96 → 558

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:154 → 195

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:95 → 141

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:488 → 555

SWIRM; SWIRM domain
NM_001170174.2 → NP_001163645.1 transcriptional adaptor 2a, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163645.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JIP2

Conserved Domains (4) summary

COG5114
Location:81 → 523

COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

cd00167
Location:139 → 180

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02335
Location:80 → 126

ZZ_ADA2; Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam04433
Location:453 → 520

SWIRM; SWIRM domain