Ccn4 cellular communication network factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccn4provided by MGI
Official Full Name: cellular communication network factor 4provided by MGI
Primary source: MGI:MGI:1197008
See related: Ensembl:ENSMUSG00000005124 AllianceGenome:MGI:1197008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Elm1; Wisp1
Summary: Predicted to enable heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of cell differentiation; osteoblast differentiation; and osteoclast differentiation. Located in cytoplasm. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and skeleton. Orthologous to human CCN4 (cellular communication network factor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in limb E14.5 (RPKM 9.0), ovary adult (RPKM 6.7) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D2; 15 29.3 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (66763337..66795050)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (66891369..66923201)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TGF-beta1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
Title: The TGF-β1 target WISP1 is highly expressed in liver cirrhosis and cirrhotic HCC microenvironment and involved in pro- and anti-tumorigenic effects.
WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing.
Title: WISP-1 Regulates Cardiac Fibrosis by Promoting Cardiac Fibroblasts' Activation and Collagen Processing.
HuR-dependent expression of Wisp1 is necessary for TGFbeta-induced cardiac myofibroblast activity.
Title: HuR-dependent expression of Wisp1 is necessary for TGFβ-induced cardiac myofibroblast activity.
Analysis of CCN4/WISP1 Effects on Joint Tissues Using Gain- and Loss-of-Function Approaches.
Title: Analysis of CCN4/WISP1 Effects on Joint Tissues Using Gain- and Loss-of-Function Approaches.
WNT1-inducible signalling pathway protein 1 stabilizes atherosclerotic plaques in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway.
Title: WNT1-inducible signalling pathway protein 1 stabilizes atherosclerotic plaques in apolipoprotein-E-deficient mice via the focal adhesion kinase/mitogen-activated extracellular signal-regulated kinase/extracellular signal-regulated kinase pathway.
LncRNA Gm12840 mediates WISP1 to regulate ischemia-reperfusion-induced renal fibrosis by sponging miR-677-5p.
Title: LncRNA Gm12840 mediates WISP1 to regulate ischemia-reperfusion-induced renal fibrosis by sponging miR-677-5p.
Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.
Title: Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification.
WISP1 alleviates lipid deposition in macrophages via the PPARgamma/CD36 pathway in the plaque formation of atherosclerosis.
Title: WISP1 alleviates lipid deposition in macrophages via the PPARγ/CD36 pathway in the plaque formation of atherosclerosis.
WNT1-inducible-signaling pathway protein 1 regulates the development of kidney fibrosis through the TGF-beta1 pathway.
Title: WNT1-inducible-signaling pathway protein 1 regulates the development of kidney fibrosis through the TGF-β1 pathway.
Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1.
Title: Mechanical stimulations can inhibit local and remote tumor progression by downregulating WISP1.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW146261 (e-PCR)
- UniSTS:180766

Wisp1 (e-PCR), detects polymorphism
- UniSTS:144768

ha2080 (e-PCR)
- UniSTS:515484

AB004873 (e-PCR)
- UniSTS:186025

Wisp1 (e-PCR), detects polymorphism
- UniSTS:532696

NoName (e-PCR)
- UniSTS:237311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: CCN family member 4

Names: WNT1 inducible signaling pathway protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018865.4 → NP_061353.1 CCN family member 4 precursor

See identical proteins and their annotated locations for NP_061353.1

Status: VALIDATED

Source sequence(s)

AC107859

Consensus CDS

CCDS27510.1

UniProtKB/Swiss-Prot

O54775, Q80ZL1

UniProtKB/TrEMBL

Q3UFJ5

Related

ENSMUSP00000005255.3, ENSMUST00000005255.9

Conserved Domains (3) summary

smart00214
Location:123 → 181

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:49 → 101

IGFBP; Insulin-like growth factor binding protein

cl15278
Location:220 → 259

TSP_1; Thrombospondin type 1 domain