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    veli veli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43003, updated on 9-Dec-2024

    Summary

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    Official Symbol
    veliprovided by FlyBase
    Official Full Name
    veliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039269
    Locus tag
    Dmel_CG7662
    See related
    AllianceGenome:FB:FBgn0039269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7662; d-Veli; D-veli; dLin-7; DLin-7; dLin7; DLin7; Dmel\CG7662; dVeli; Dveli; Flin-7; lin-7; Lin-7; lin7; Lin7; LIN7; Veli
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Involved in border follicle cell migration and regulation of synaptic assembly at neuromuscular junction. Located in postsynaptic membrane. Part of subapical complex. Is expressed in several structures, including adult head; embryonic/larval neuromuscular junction; epithelium; gut section; and synaptic neuropil domain. Orthologous to several human genes including LIN7B (lin-7 homolog B, crumbs cell polarity complex component) and LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See veli in Genome Data Viewer
    Location:
    96B19-96B19; 3-86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25064418..25065591, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20890140..20891313, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene staccato Neighboring gene Poly-glutamine tract binding protein 1 Neighboring gene Catalytic subunit 3B of the oligosaccharyltransferase complex Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila. Soukup SF, et al. Curr Biol, 2013 Jul 22. PMID 23850283
    2. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97. Bachmann A, et al. J Cell Sci, 2004 Apr 15. PMID 15039455
    3. Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration. Bachmann A, et al. Eur J Cell Biol, 2008 Mar. PMID 18177979
    4. Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila. Bulgakova NA, et al. J Cell Sci, 2008 Jun 15. PMID 18495840
    5. Crumbs regulates polarity and prevents light-induced degeneration of the simple eyes of Drosophila, the ocelli. Mishra M, et al. Eur J Cell Biol, 2012 Sep. PMID 22608020

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. At the photoreceptor synapse, DLin-7 acts as part of a conserved DLin-7/CASK/DlgS97 complex required to control the number of capitate projections and active zones, important specializations in the that are essential for proper neurotransmission.
      Title: DLin-7 is required in postsynaptic lamina neurons to prevent light-induced photoreceptor degeneration in Drosophila.
    2. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization
      Title: A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions.
    3. study reports that Lin-7, a scaffolding protein with one Lin-2/Lin-7 domain & one PSD-95/Dlg/ZO-1 domain, is associated with the Crumbs complex in subapical region of embryonic & follicle epithelia & at the stalk membrane of adult photoreceptor cells
      Title: Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration.
    4. recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms; DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses [VELI is a synonym for Lin-7]
      Title: Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic assembly at neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of subapical complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    veli
    Names
    CG7662-PA
    CG7662-PC
    veli-PA
    veli-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25064418..25065591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143073.4 → NP_651330.1  veli, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBY7
      Related
      FBpp0084162
      Conserved Domains (2) summary
      cd00992
      Location:91 → 172
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:14 → 66
      L27; L27 domain

    2. NM_170197.3 → NP_733076.2  veli, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733076.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL82, Q8IMT8
      Conserved Domains (2) summary
      cd00992
      Location:153 → 223
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:14 → 66
      L27; L27 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IMT8 Q8IMT8
    Q9VBY7 Q9VBY7

    Gene LinkOut

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