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    Polr3e polymerase (RNA) III (DNA directed) polypeptide E [ Mus musculus (house mouse) ]

    Gene ID: 26939, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Polr3eprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Eprovided by MGI
    Primary source
    MGI:MGI:1349452
    See related
    Ensembl:ENSMUSG00000030880 AllianceGenome:MGI:1349452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sin; RPC5
    Summary
    Predicted to be involved in DNA-templated transcription; defense response to virus; and innate immune response. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human POLR3E (RNA polymerase III subunit E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 10.6), limb E14.5 (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr3e in Genome Data Viewer
    Location:
    7 F2; 7 65.01 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (120516960..120546658)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (120917778..120947435)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene eukaryotic elongation factor-2 kinase Neighboring gene predicted gene 15774 Neighboring gene STARR-positive B cell enhancer ABC_E2845 Neighboring gene STARR-positive B cell enhancer ABC_E6593 Neighboring gene nuclear encoded tRNA leucine 4 (anticodon AAG) Neighboring gene cerebellar degeneration-related 2 Neighboring gene STARR-positive B cell enhancer ABC_E450 Neighboring gene major facilitator superfamily domain containing 13B Neighboring gene predicted pseudogene 9234

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene. Yeganeh M, et al. Genes Dev, 2017 Feb 15. PMID 28289142, Free PMC Article
    2. SIN, a novel Drosophila protein that associates with the RNA binding protein sex-lethal. Dong Z, et al. Gene, 1999 Sep 17. PMID 10521666
    3. Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. Danzl NM, et al. J Exp Med, 2010 May 10. PMID 20404100, Free PMC Article
    4. Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling. Riccomagno MM, et al. Neuron, 2014 Feb 19. PMID 24559672, Free PMC Article
    5. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, affects Polr3e expression through transcriptional interference
      Title: Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene.
    2. Results identify Sin as a novel regulator of medullary thymic epithelial cell development and t cell tolerance.
      Title: Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC5
    Names
    RNA polymerase III polypeptide E
    RNA polymerase III subunit 5
    RNA polymerase III subunit C5
    sex-lethal interactor homolog
    sxl interactor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164096.2 → NP_001157568.1  DNA-directed RNA polymerase III subunit RPC5 isoform 2

      See identical proteins and their annotated locations for NP_001157568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC122248
      Consensus CDS
      CCDS52383.1
      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Related
      ENSMUSP00000146970.2, ENSMUST00000207481.2
      Conserved Domains (1) summary
      pfam04801
      Location:5 → 406
      Sin_N; Sin-like protein conserved region

    2. NM_001379288.1 → NP_001366217.1  DNA-directed RNA polymerase III subunit RPC5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC122248
      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Conserved Domains (1) summary
      pfam04801
      Location:5 → 436
      Sin_N; Sin-like protein conserved region

    3. NM_025298.4 → NP_079574.2  DNA-directed RNA polymerase III subunit RPC5 isoform 1

      See identical proteins and their annotated locations for NP_079574.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC122248
      Consensus CDS
      CCDS21797.1
      UniProtKB/Swiss-Prot
      Q8CI35, Q9CZT4, Q9DBD1
      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Related
      ENSMUSP00000033173.8, ENSMUST00000033173.15
      Conserved Domains (1) summary
      pfam04801
      Location:5 → 432
      Sin_N; Sin-like protein conserved region

    RNA

    1. NR_166590.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122248

    2. NR_166591.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122248

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      120516960..120546658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322284.3 → XP_017177773.1  DNA-directed RNA polymerase III subunit RPC5 isoform X1

      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Conserved Domains (1) summary
      pfam04801
      Location:5 → 431
      Sin_N; Sin-like protein conserved region

    2. XM_036153139.1 → XP_036009032.1  DNA-directed RNA polymerase III subunit RPC5 isoform X3

      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Conserved Domains (1) summary
      pfam04801
      Location:1 → 396
      Sin_N; Sin-like protein conserved region

    3. XM_006507887.4 → XP_006507950.1  DNA-directed RNA polymerase III subunit RPC5 isoform X4

      UniProtKB/TrEMBL
      Q3UJW8
      Conserved Domains (1) summary
      pfam04801
      Location:7 → 321
      Sin_N; Sin-like protein conserved region

    4. XM_036153138.1 → XP_036009031.1  DNA-directed RNA polymerase III subunit RPC5 isoform X2

      UniProtKB/TrEMBL
      Q3TWE8, Q3UJW8
      Conserved Domains (1) summary
      pfam04801
      Location:1 → 400
      Sin_N; Sin-like protein conserved region

    RNA

    1. XR_004934106.1 RNA Sequence

    2. XR_004934107.1 RNA Sequence

    3. XR_004934105.1 RNA Sequence

    4. XR_001785562.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZT4.2 GenPept UniProtKB/Swiss-Prot:Q9CZT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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