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    Trmt61 tRNA methyltransferase 61 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43170, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trmt61provided by FlyBase
    Official Full Name
    tRNA methyltransferase 61provided by FlyBase
    Primary source
    FLYBASE:FBgn0039407
    Locus tag
    Dmel_CG14544
    See related
    AllianceGenome:FB:FBgn0039407
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14544; Dmel\CG14544; TRMT61A
    Summary
    Predicted to enable tRNA (adenine(58)-N1)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Orthologous to human TRMT61A (tRNA methyltransferase 61A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trmt61 in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26059496..26061293)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21885218..21887015)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class P Neighboring gene Ribosomal protein L34a Neighboring gene Threonyl-carbamoyl synthesis 6 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44950 Neighboring gene dysfusion Neighboring gene long non-coding RNA:CR44319

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dysregulated mitochondrial and cytosolic tRNA m1A methylation in Alzheimer's disease. Shafik AM, et al. Hum Mol Genet, 2022 May 19. PMID 34897434, Free PMC Article
    2. A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Shen J, et al. Aging (Albany NY), 2009 Jan 30. PMID 20157509, Free PMC Article
    3. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006
    4. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624
    5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA methyltransferase 61
    Names
    CG14544-PA
    CG14544-PB
    Trmt61-PA
    Trmt61-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26059496..26061293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143204.3 → NP_651461.1  tRNA methyltransferase 61, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651461.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBH7
      Related
      FBpp0084342
      Conserved Domains (1) summary
      pfam08704
      Location:72 → 310
      GCD14; tRNA methyltransferase complex GCD14 subunit

    2. NM_001316555.1 → NP_001303484.1  tRNA methyltransferase 61, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBH7
      Conserved Domains (1) summary
      pfam08704
      Location:72 → 310
      GCD14; tRNA methyltransferase complex GCD14 subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBH7 Q9VBH7

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