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    CG14062 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG14062provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039592
    Locus tag
    Dmel_CG14062
    See related
    AllianceGenome:FB:FBgn0039592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14062; LP23408p
    Summary
    Predicted to enable RNA endonuclease activity and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14062 in Genome Data Viewer
    Location:
    98D7-98D7; 3-96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28641585..28642891, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24467307..24468613, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity. Pinnola A, et al. J Biol Chem, 2007 Nov 2. PMID 17827147
    2. A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. Pauli A, et al. Curr Biol, 2010 Oct 26. PMID 20933422, Free PMC Article
    3. Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function. Zraly CB, et al. J Biol Chem, 2006 Nov 17. PMID 16990270
    4. Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Schertel C, et al. Dev Cell, 2013 Apr 29. PMID 23583758
    5. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14062-PB
    NP_001034074.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28641585..28642891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038985.2 → NP_001034074.1  uncharacterized protein Dmel_CG14062 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLM9, Q9VAU3
      Conserved Domains (1) summary
      pfam01223
      Location:102 → 344
      Endonuclease_NS; DNA/RNA non-specific endonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAU3 Q9VAU3

    Gene LinkOut

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