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    CG2126 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2126provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039876
    Locus tag
    Dmel_CG2126
    See related
    AllianceGenome:FB:FBgn0039876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.412; Dmel\CG2126
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in ERAD pathway. Predicted to be located in membrane. Is expressed in organism. Orthologous to human JKAMP (JNK1/MAPK8 associated membrane protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2126 in Genome Data Viewer
    Location:
    100D2-100D2; 3-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31775049..31776652, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27600771..27602374, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43436 Neighboring gene antisense RNA:CR33945 Neighboring gene beta glucuronidase Neighboring gene septin interacting protein 3 Neighboring gene fat facets Neighboring gene Methylcrotonoyl-CoA carboxylase 1 Neighboring gene ATP-dependent chromatin assembly factor large subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. highroad Is a Carboxypetidase Induced by Retinoids to Clear Mutant Rhodopsin-1 in Drosophila Retinitis Pigmentosa Models. Huang HW, et al. Cell Rep, 2018 Feb 6. PMID 29425495, Free PMC Article
    2. Integration of UPRER and oxidative stress signaling in the control of intestinal stem cell proliferation. Wang L, et al. PLoS Genet, 2014 Aug. PMID 25166757, Free PMC Article
    3. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Molnar C, et al. Genetics, 2006 Nov. PMID 16980395, Free PMC Article
    4. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2126-PA
    CG2126-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31775049..31776652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143638.4 → NP_651895.2  uncharacterized protein Dmel_CG2126, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651895.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXK7, Q9V9T7
      Related
      FBpp0085216
      Conserved Domains (1) summary
      pfam05571
      Location:10 → 294
      DUF766; Protein of unknown function (DUF766)

    2. NM_001276224.2 → NP_001263153.1  uncharacterized protein Dmel_CG2126, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHY1
      Conserved Domains (1) summary
      pfam05571
      Location:10 → 294
      DUF766; Protein of unknown function (DUF766)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHY1 A0A0B4KHY1
    Q8SXK7 Q8SXK7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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