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    egh egghead [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eghprovided by FlyBase
    Official Full Name
    eggheadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001404
    Locus tag
    Dmel_CG9659
    See related
    AllianceGenome:FB:FBgn0001404
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ManT; beta1; CG9659; Dmel\CG9659; EG:BACR25B3.8; Egh; l(1)3Ae; l(1)zw4; zw-4; ZW-4; zw4
    Summary
    Enables beta-1,4-mannosyltransferase activity. Involved in several processes, including dsRNA transport; neuron development; and oogenesis. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; adult fat body; adult head; ganglia; and germline cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See egh in Genome Data Viewer
    Location:
    3A6-3A6; 1-1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2588503..2599111)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2482536..2493144)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Arylalkylamine N-acetyltransferase-like 7 Neighboring gene uncharacterized protein Neighboring gene will die slowly Neighboring gene Kinesin-like protein at 3A Neighboring gene Zeste-white 10 Neighboring gene SET and MYND domain containing, class 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The egghead gene product influences oocyte differentiation by follicle cell-germ cell interactions in Drosophila melanogaster. Rübsam R, et al. Mech Dev, 1998 Mar. PMID 9533964
    2. Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac. Wandall HH, et al. J Biol Chem, 2003 Jan 17. PMID 12454022
    3. Sex-peptide-regulated female sexual behavior requires a subset of ascending ventral nerve cord neurons. Soller M, et al. Curr Biol, 2006 Sep 19. PMID 16979554
    4. Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C. Eberwein AE, et al. Dis Model Mech, 2023 Oct 1. PMID 37815467, Free PMC Article
    5. Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo. Wandall HH, et al. J Biol Chem, 2005 Feb 11. PMID 15611100

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The egghead gene provides an essential component to the Sex-peptide response.
      Title: Sex-peptide-regulated female sexual behavior requires a subset of ascending ventral nerve cord neurons.
    2. encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac
      Title: Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac.
    3. The egghead gene (egh) encoding a glycosyltransferase is required for a compartment boundary between lamina glia and lobula cortex, which is necessary for appropriate R1-R6 innervation of the lamina.
      Title: The egghead gene is required for compartmentalization in Drosophila optic lobe development.
    4. Egghead and brainiac are essential for glycosphingolipid biosynthesis
      Title: Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-1,4-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,4-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-1,4-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insect visual primordium formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of polarity of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    egghead
    Names
    CG9659-PB
    CG9659-PC
    CG9659-PD
    beta1,4-mannosyltransferase
    egh-PB
    egh-PC
    egh-PD
    zeste-white 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2588503..2599111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080313.3 → NP_525052.1  egghead, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01346, O01347, Q9V3B0
      UniProtKB/TrEMBL
      A4V3W0, C0PTV2
      Related
      FBpp0070423
      Conserved Domains (2) summary
      COG1215
      Location:283 → 435
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      pfam13632
      Location:184 → 372
      Glyco_trans_2_3; Glycosyl transferase family group 2

    2. NM_166946.2 → NP_726818.1  egghead, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01346, O01347, Q9V3B0
      UniProtKB/TrEMBL
      A4V3W0, C0PTV2
      Related
      FBpp0070424
      Conserved Domains (2) summary
      COG1215
      Location:283 → 435
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      pfam13632
      Location:184 → 372
      Glyco_trans_2_3; Glycosyl transferase family group 2

    3. NM_001297900.1 → NP_001284829.1  egghead, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01346, O01347, Q9V3B0
      UniProtKB/TrEMBL
      A4V3W0, C0PTV2
      Conserved Domains (2) summary
      COG1215
      Location:283 → 435
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      pfam13632
      Location:184 → 372
      Glyco_trans_2_3; Glycosyl transferase family group 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V3W0 A4V3W0
    O01346.1 O01346
    Q95ST6 Q95ST6

    Gene LinkOut

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