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    sov small ovary [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31615, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sovprovided by FlyBase
    Official Full Name
    small ovaryprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287725
    Locus tag
    Dmel_CG14438
    See related
    AllianceGenome:FB:FBgn0287725
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14438; Dmel\CG14438; EM25; fs(1)A1304; fs(1)M105; l(1)6Dc; l(1)EA42; l(1)EM25; Sov
    Summary
    Involved in piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; ganglia; germarium region 1; germline cell; and somatic cell of ovariole. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sov in Genome Data Viewer
    Location:
    6C12-6C13; 1-18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6756322..6770712)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6650355..6664745)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44895 Neighboring gene long non-coding RNA:CR44964 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43496 Neighboring gene Coenzyme Q7 Neighboring gene shifted Neighboring gene C3G guanyl-nucleotide exchange factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. fs(1)A1304(1) is a 5' UTR deletion of the essential gene small ovary in Drosophila. Hammond M, et al. MicroPubl Biol, 2020 May 6. PMID 32550484, Free PMC Article
    2. Genetic characterization of small ovaries, a gene required in the soma for the development of the Drosophila ovary and the female germline. Wayne S, et al. Genetics, 1995 Mar. PMID 7768440, Free PMC Article
    3. Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Benner L, et al. Genetics, 2019 Nov. PMID 31558581, Free PMC Article
    4. Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Andreev VI, et al. Nat Struct Mol Biol, 2022 Feb. PMID 35173350
    5. Regulatory and functional interactions between ovarian tumor and ovo during Drosophila oogenesis. Hinson S, et al. Mech Dev, 1999 Oct. PMID 10525184

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 6757291-6758456 mobile_element_type = transposon:1360{}76
    • Loc: 6770583-6770641 mobile_element_type = transposon:FB{}3535

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ovary
    Names
    CG14438-PA
    CG14438-PB
    CG14438-PC
    female sterile (1) A1304
    female sterile(1)M105
    lethal (1) 6Dc
    sov-PA
    sov-PB
    sov-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6756322..6770712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132120.2 → NP_572348.1  small ovary, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W6
      Related
      FBpp0070922
      Conserved Domains (1) summary
      pfam16031
      Location:2032 → 2077
      TonB_N; TonB N-terminal region

    2. NM_167090.2 → NP_727123.1  small ovary, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W6
      Related
      FBpp0070923
      Conserved Domains (1) summary
      pfam16031
      Location:2032 → 2077
      TonB_N; TonB N-terminal region

    3. NM_001298033.1 → NP_001284962.1  small ovary, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3W6
      Conserved Domains (1) summary
      pfam16031
      Location:2032 → 2077
      TonB_N; TonB N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3W6 Q9W3W6

    Gene LinkOut

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