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    FASN2 Fatty acid synthase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FASN2provided by FlyBase
    Official Full Name
    Fatty acid synthase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0042627
    Locus tag
    Dmel_CG3524
    See related
    AllianceGenome:FB:FBgn0042627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3524; Dmel\CG3524; DM_7295849; FAS; FAS-mb; FAS2; fasn; FASN; fasn2; FASN[CG3524]; FAS[CG3524]; mFAS; v(2)k05816
    Summary
    Enables fatty acid synthase activity. Involved in cellular response to sucrose stimulus; cuticle hydrocarbon biosynthetic process; and methyl-branched fatty acid biosynthetic process. Is expressed in adult head; adult heart; and adult oenocyte. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See FASN2 in Genome Data Viewer
    Location:
    23C5-23C5; 2-8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3043947..3056143)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3043947..3056143)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U5 at 23D Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA Like U Neighboring gene Fatty acid synthase 1 Neighboring gene toucan Neighboring gene Protein phosphatase D6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Desiccation resistance differences in Drosophila species can be largely explained by variations in cuticular hydrocarbons. Wang Z, et al. Elife, 2022 Dec 6. PMID 36473178, Free PMC Article
    2. A single gene affects both ecological divergence and mate choice in Drosophila. Chung H, et al. Science, 2014 Mar 7. PMID 24526311
    3. Drosophila STING protein has a role in lipid metabolism. Akhmetova K, et al. Elife, 2021 Sep 1. PMID 34467853, Free PMC Article
    4. tRNA-derived small RNAs are embedded in the gene regulatory network instructing Drosophila metamorphosis. Shi J, et al. Genome Res, 2023 Dec 27. PMID 37973194, Free PMC Article
    5. Social perception of young adults prolongs the lifespan of aged Drosophila. Cho LC, et al. NPJ Aging Mech Dis, 2021 Sep 1. PMID 34471134, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [acyl-carrier-protein] S-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fatty acid synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to sucrose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cuticle hydrocarbon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methyl-branched fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid synthase 2
    Names
    CG3524-PA
    CG3524-PB
    FASN2-PA
    FASN2-PB
    fatty acid synthase, methyl-branched specific
    mbCHC-specific FAS
    methyl-branched specific FAS
    v(2)k05816
    NP_001259986.1
    NP_647613.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3043947..3056143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273057.2 → NP_001259986.1  fatty acid synthase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PB21
      Conserved Domains (11) summary
      cd05195
      Location:1473 → 1761
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:1780 → 2018
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:2031 → 2083
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:1471 → 1761
      PKS_ER; Enoylreductase
      COG3321
      Location:15 → 1043
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:18 → 423
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:381 → 498
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:875 → 1072
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:518 → 835
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1263 → 1429
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2159 → 2408
      Abhydrolase; alpha/beta hydrolases

    2. NM_139356.2 → NP_647613.1  fatty acid synthase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQL6
      Related
      FBpp0077342
      Conserved Domains (11) summary
      cd05195
      Location:1473 → 1761
      enoyl_red; enoyl reductase of polyketide synthase
      cd08954
      Location:1780 → 2018
      KR_1_FAS_SDR_x; beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 1, complex (x) SDRs
      smart00823
      Location:2031 → 2083
      PKS_PP; Phosphopantetheine attachment site
      smart00829
      Location:1471 → 1761
      PKS_ER; Enoylreductase
      COG3321
      Location:15 → 1043
      PksD; Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism]
      cd00833
      Location:18 → 423
      PKS; polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or ...
      pfam16197
      Location:381 → 498
      KAsynt_C_assoc; Ketoacyl-synthetase C-terminal extension
      cl00509
      Location:875 → 1072
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl08282
      Location:518 → 835
      Acyl_transf_1; Acyl transferase domain
      cl21454
      Location:1263 → 1429
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
      cl21494
      Location:2159 → 2407
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB21 M9PB21
    Q8MR70 Q8MR70
    Q9VQL6 Q9VQL6

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