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    mtTFB2 mitochondrial transcription factor B2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtTFB2provided by FlyBase
    Official Full Name
    mitochondrial transcription factor B2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037778
    Locus tag
    Dmel_CG3910
    See related
    AllianceGenome:FB:FBgn0037778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3910; d-mtTFB2; d-TF2BM; Dmel\CG3910; TFB2; TFB2M
    Summary
    Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Involved in mitochondrial transcription. Located in mitochondrion. Is expressed in organism. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtTFB2 in Genome Data Viewer
    Location:
    85F8-85F8; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10045574..10047260)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5871296..5872982)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44192 Neighboring gene ohgata Neighboring gene fancl Neighboring gene Niemann-Pick type C-2e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila nuclear factor DREF regulates the expression of the mitochondrial DNA helicase and mitochondrial transcription factor B2 but not the mitochondrial translation factor B1. Fernández-Moreno MA, et al. Biochim Biophys Acta, 2013 Oct. PMID 23916463, Free PMC Article
    2. Drosophila mitochondrial transcription factor B2 regulates mitochondrial DNA copy number and transcription in schneider cells. Matsushima Y, et al. J Biol Chem, 2004 Jun 25. PMID 15060065
    3. Modulation of mitochondrial nucleoid structure during aging and by mtDNA content in Drosophila. Wang LJ, et al. Biol Open, 2021 Jun 15. PMID 34180963, Free PMC Article
    4. EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation. Zhang C, et al. Curr Biol, 2022 Sep 12. PMID 35896119, Free PMC Article
    5. Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development. Adán C, et al. J Biol Chem, 2008 May 2. PMID 18308726, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mitochondrial transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mitochondrial transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at mitochondrial promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial transcription factor B2
    Names
    CG3910-PA
    mtTFB2-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10045574..10047260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141714.4 → NP_649971.1  mitochondrial transcription factor B2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649971.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95SS3, Q9VH38
      Related
      FBpp0081651
      Conserved Domains (1) summary
      cl17173
      Location:69 → 309
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH38.2 Q9VH38

    Gene LinkOut

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