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    Wdr82 WD repeat domain 82 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34153, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr82provided by FlyBase
    Official Full Name
    WD repeat domain 82provided by FlyBase
    Primary source
    FLYBASE:FBgn0032030
    Locus tag
    Dmel_CG17293
    See related
    AllianceGenome:FB:FBgn0032030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17293; Dmel\CG17293; dWdr82; wdr-82; wdr82; WDR82
    Summary
    Predicted to enable chromatin binding activity. Involved in negative regulation of DNA-templated transcription, elongation and nuclear RNA surveillance. Part of Set1C/COMPASS complex. Is expressed in several structures, including adult head; central brain primordium; ganglia; larval central nervous system; and ventral nerve cord primordium. Orthologous to human WDR82 (WD repeat domain 82). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr82 in Genome Data Viewer
    Location:
    29B2-29B3; 2-31 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8374461..8375549)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8374461..8375549)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 2A at 29B Neighboring gene antisense RNA:CR45341 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Alanyl-tRNA synthetase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dSet1 is the main H3K4 di- and tri-methyltransferase throughout Drosophila development. Hallson G, et al. Genetics, 2012 Jan. PMID 22048023, Free PMC Article
    2. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article
    3. Molecular organization of Drosophila neuroendocrine cells by Dimmed. Park D, et al. Curr Biol, 2011 Sep 27. PMID 21885285, Free PMC Article
    4. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. Ciurciu A, et al. PLoS Genet, 2013 Oct. PMID 24204300, Free PMC Article
    5. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Berson A, et al. Curr Biol, 2017 Dec 4. PMID 29153328, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identify Wdr82 as a component of this process and show that it works with Su(s) to inhibit Pol II elongation through Hsp70-alphabeta elements
      Title: Suppressor of sable [Su(s)] and Wdr82 down-regulate RNA from heat-shock-inducible repetitive elements by a mechanism that involves transcription termination.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear RNA surveillance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat domain 82
    Names
    CG17293-PA
    Wdr82-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8374461..8375549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135373.3 → NP_609217.1  WD repeat domain 82 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLN1
      Related
      FBpp0079266
      Conserved Domains (2) summary
      cd00200
      Location:17 → 302
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:26 → 63
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLN1.1 Q9VLN1

    Gene LinkOut

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