U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hap40 Huntingtin-associated protein 40 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32507, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hap40provided by FlyBase
    Official Full Name
    Huntingtin-associated protein 40 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030671
    Locus tag
    Dmel_CG8134
    See related
    AllianceGenome:FB:FBgn0030671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg8134; CG8134; dhap40; Dmel\CG8134
    Summary
    Involved in protein stabilization. Predicted to be active in early endosome. Orthologous to human F8A1 (coagulation factor VIII associated 1); F8A2 (coagulation factor VIII associated 2); and F8A3 (coagulation factor VIII associated 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hap40 in Genome Data Viewer
    Location:
    13E8-13E8; 1-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15704125..15705806)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15598158..15599839)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol synthase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. HAP40 is a conserved central regulator of Huntingtin and a potential modulator of Huntington's disease pathogenesis. Xu S, et al. PLoS Genet, 2022 Jul. PMID 35853002, Free PMC Article
    2. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
    3. Toward a comprehensive map of the effectors of rab GTPases. Gillingham AK, et al. Dev Cell, 2014 Nov 10. PMID 25453831, Free PMC Article
    4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
    5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in vesicle cytoskeletal trafficking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Huntingtin-associated protein 40 kDa
    Names
    CG8134-PA
    CG8134-PB
    Hap40-PA
    Hap40-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15704125..15705806
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298354.1 → NP_001285283.1  Huntingtin-associated protein 40 kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285283.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXR6

    2. NM_132828.2 → NP_573056.1  Huntingtin-associated protein 40 kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXR6
      Related
      FBpp0073870
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXR6 Q9VXR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools