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    Spn88Ea Serpin 88Ea [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spn88Eaprovided by FlyBase
    Official Full Name
    Serpin 88Eaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028984
    Locus tag
    Dmel_CG18525
    See related
    AllianceGenome:FB:FBgn0028984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18525; Dmel\CG18525; sp5; Sp5; spn5; Spn5
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Involved in imaginal disc-derived wing expansion; negative regulation of innate immune response; and negative regulation of protein metabolic process. Located in extracellular region. Is expressed in several structures, including adult head; embryonic anal pad; female germline cell; gut section; and primary tracheal branch. Human ortholog(s) of this gene implicated in intermediate coronary syndrome; neurodegenerative disease (multiple); thrombophilia (multiple); thrombosis; and toxic shock syndrome. Orthologous to several human genes including SERPINA12 (serpin family A member 12); SERPINB1 (serpin family B member 1); and SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spn88Ea in Genome Data Viewer
    Location:
    88E3-88E3; 3-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15203069..15206447, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11028791..11032169, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Eb Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. Charron Y, et al. Int J Dev Biol, 2008. PMID 18956323
    2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
    3. A novel Drosophila serpin that inhibits serine proteases. Han J, et al. FEBS Lett, 2000 Feb 25. PMID 10692585
    4. Elimination of oncogenic cells that regulate epithelial homeostasis in Drosophila. Ohsawa S. Dev Growth Differ, 2019 Jun. PMID 30957223, Free PMC Article
    5. Spatial regulation of developmental signaling by a serpin. Hashimoto C, et al. Dev Cell, 2003 Dec. PMID 14667416

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests that Spn5 secreted from normal epithelial cells acts as a component of the extracellular surveillance system that facilitates elimination of pre-malignant cells from epithelium.
      Title: Serpin Facilitates Tumor-Suppressive Cell Competition by Blocking Toll-Mediated Yki Activation in Drosophila.
    2. Spn5 is a regulator of the Toll pathway and CHMP2B toxicity and the Toll pathway is a major signaling pathway misregulated by mutant CHMP2B in vivo.
      Title: Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia.
    3. Spn5 is essential for wing expansion in Drosophila melanogaster.
      Title: The serpin Spn5 is essential for wing expansion in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Toll receptor ligand protein activation cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin 88Ea
    Names
    CG18525-PA
    CG18525-PB
    Dm-serpin-88Ea
    Spn88Ea-PA
    Spn88Ea-PB
    serine protease inhibitor 5
    serpin
    serpin 5
    serpin5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15203069..15206447 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176501.3 → NP_788678.1  serpin 88Ea, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1I4, Q9VFC2
      Related
      FBpp0082596
      Conserved Domains (1) summary
      cd00172
      Location:39 → 419
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_080215.4 → NP_524954.2  serpin 88Ea, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524954.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1I4, Q9VFC2
      Related
      FBpp0082595
      Conserved Domains (1) summary
      cd00172
      Location:39 → 419
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFC2.1 Q9VFC2

    Gene LinkOut

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