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    Gk2 Glycerol kinase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38221, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gk2provided by FlyBase
    Official Full Name
    Glycerol kinase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035266
    Locus tag
    Dmel_CG7995
    See related
    AllianceGenome:FB:FBgn0035266
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7995; dGK; Dmel\CG7995; Gk; GK2
    Summary
    Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase); GK2 (glycerol kinase 2); and GK3 (glycerol kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gk2 in Genome Data Viewer
    Location:
    62B1-62B1; 3-1.0 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1738407..1745421)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1738407..1745421)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene draper Neighboring gene Outer segment 4 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W b Neighboring gene uncharacterized protein Neighboring gene Chitinase 2 Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 62B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development. Zhang H, et al. PLoS Biol, 2018 Jul. PMID 30028832, Free PMC Article
    2. Disruption of glycerol metabolism by RNAi targeting of genes encoding glycerol kinase results in a range of phenotype severity in Drosophila. Wightman PJ, et al. PLoS One, 2013. PMID 24039719, Free PMC Article
    3. Conserved family of glycerol kinase loci in Drosophila melanogaster. Martinez Agosto JA, et al. Mol Genet Metab, 2006 Aug. PMID 16545593, Free PMC Article
    4. Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. Wightman PJ, et al. PLoS One, 2012. PMID 22427807, Free PMC Article
    5. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Fukunaga R, et al. Cell, 2012 Oct 26. PMID 23063653, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 1740909-1741094 mobile_element_type = transposon:pogo{}909

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol-3-phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycerol kinase 2
    Names
    CG7995-PA
    CG7995-PB
    CG7995-PC
    CG7995-PD
    CG7995-PE
    CG7995-PF
    Gk2-PA
    Gk2-PB
    Gk2-PC
    Gk2-PD
    Gk2-PE
    Gk2-PF
    glycerol kinase
    NP_001286904.1
    NP_647655.1
    NP_728664.1
    NP_728665.1
    NP_728666.1
    NP_728667.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1738407..1745421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299975.1 → NP_001286904.1  glycerol kinase 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase

    2. NM_167913.3 → NP_728665.1  glycerol kinase 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728665.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Related
      FBpp0072650
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase

    3. NM_167915.3 → NP_728667.1  glycerol kinase 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728667.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Related
      FBpp0072651
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase

    4. NM_167914.2 → NP_728666.1  glycerol kinase 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Related
      FBpp0072652
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase

    5. NM_167912.2 → NP_728664.1  glycerol kinase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Related
      FBpp0072653
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase

    6. NM_139398.3 → NP_647655.1  glycerol kinase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961K9, Q9W094, Q9W095
      Related
      FBpp0072654
      Conserved Domains (2) summary
      cd07792
      Location:31 → 533
      FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
      TIGR01311
      Location:31 → 533
      glycerol_kin; glycerol kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961K9 Q961K9
    Q9W095 Q9W095

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