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    CG5969 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5969provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036998
    Locus tag
    Dmel_CG5969
    See related
    AllianceGenome:FB:FBgn0036998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM09417; BcDNA:RE53796; CG32426; Dmel\CG5969
    Summary
    Predicted to be involved in vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in X-linked myopathy with excessive autophagy. Orthologous to human VMA21 (vacuolar ATPase assembly factor VMA21). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5969 in Genome Data Viewer
    Location:
    77C4-77C4; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20473783..20474791)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20466883..20467891)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene L-threonine dehydrogenase Neighboring gene uncharacterized protein Neighboring gene iso Glutaminyl cyclase Neighboring gene Zinc transporter 77C Neighboring gene NADH dehydrogenase (ubiquinone) 39 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. Meisel RP. J Mol Evol, 2009 Jul. PMID 19536449
    2. Structural and Comparative Analyses of Insects Suggest the Presence of an Ultra-Conserved Regulatory Element of the Genes Encoding Vacuolar-Type ATPase Subunits and Assembly Factors. Lovero D, et al. Biology (Basel), 2023 Aug 13. PMID 37627011, Free PMC Article
    3. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
    4. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    5. Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes. Hosono C, et al. Nat Cell Biol, 2015 Dec. PMID 26551273

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5969-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20473783..20474791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176371.3 → NP_788549.1  uncharacterized protein Dmel_CG5969 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788549.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T3M1, Q9VPE4, Q9VPE5
      UniProtKB/TrEMBL
      A0A1B2ALE6
      Related
      FBpp0077856
      Conserved Domains (1) summary
      pfam09446
      Location:32 → 93
      VMA21; VMA21-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VPE4.2 Q9VPE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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