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    Targ3 Terminal ADP-ribose protein glycohydrolase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Targ3provided by FlyBase
    Official Full Name
    Terminal ADP-ribose protein glycohydrolase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0085290
    Locus tag
    Dmel_CG34261
    See related
    AllianceGenome:FB:FBgn0085290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34261; Dmel\CG34261; dTarg3
    Summary
    Predicted to enable ADP-ribosyl-[dinitrogen reductase] hydrolase activity; ADP-ribosylglutamate hydrolase activity; and purine nucleoside binding activity. Predicted to be involved in DNA damage response and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human OARD1 (O-acyl-ADP-ribose deacylase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Targ3 in Genome Data Viewer
    Location:
    78C2-78C2; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21196831..21197738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21189931..21190838)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45951 Neighboring gene parkin Neighboring gene Terminal ADP-ribose protein glycohydrolase 1 Neighboring gene Terminal ADP-ribose protein glycohydrolase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Fontana P, et al. Nat Commun, 2023 Jun 2. PMID 37268618, Free PMC Article
    2. Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase. Bu S, et al. Cell Rep, 2022 May 31. PMID 35649352
    3. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ADP-ribosyl-[dinitrogen reductase] hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-ribosylglutamate hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables purine nucleoside binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleoside metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    terminal ADP-ribose protein glycohydrolase 3
    Names
    CG34261-PB
    Targ3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21196831..21197738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104186.3 → NP_001097656.1  terminal ADP-ribose protein glycohydrolase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNW5
      Conserved Domains (1) summary
      cd02901
      Location:7 → 133
      Macro_Poa1p_like; Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8JNW5 A8JNW5

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