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    Alg11 ALG11, alpha-1,2-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40402, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg11provided by FlyBase
    Official Full Name
    ALG11, alpha-1,2-mannosyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037108
    Locus tag
    Dmel_CG11306
    See related
    AllianceGenome:FB:FBgn0037108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11306; dAlg11; Dmel\CG11306
    Summary
    Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; gland; and gut section. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Orthologous to human ALG11 (ALG11 alpha-1,2-mannosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Alg11 in Genome Data Viewer
    Location:
    78E1-78E1; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21625806..21628571)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21618906..21621671)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 1 Neighboring gene antisense RNA:CR45955 Neighboring gene Orosomucoid 1-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Harbison ST, et al. Nat Genet, 2009 Mar. PMID 19234472, Free PMC Article
    2. Inter-cell type interactions that control JNK signaling in the Drosophila intestine. Zhang P, et al. Nat Commun, 2024 Jun 28. PMID 38944657, Free PMC Article
    3. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
    4. Protein correlation profiles identify lipid droplet proteins with high confidence. Krahmer N, et al. Mol Cell Proteomics, 2013 May. PMID 23319140, Free PMC Article
    5. A computational search for box C/D snoRNA genes in the Drosophila melanogaster genome. Accardo MC, et al. Bioinformatics, 2004 Dec 12. PMID 15247100

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ALG11, alpha-1,2-mannosyltransferase
    Names
    A-1,2-mannosyltransferase
    Alg11-PA
    Alg11-PB
    CG11306-PA
    CG11306-PB
    NP_001262182.1
    NP_649340.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21625806..21628571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275253.2 → NP_001262182.1  ALG11, alpha-1,2-mannosyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262182.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP06, Q9VP07
      Conserved Domains (2) summary
      cd03806
      Location:44 → 463
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:24 → 473
      PLN02949; transferase, transferring glycosyl groups

    2. NM_141083.3 → NP_649340.1  ALG11, alpha-1,2-mannosyltransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VP06, Q9VP07
      Related
      FBpp0078076
      Conserved Domains (2) summary
      cd03806
      Location:44 → 463
      GT1_ALG11_like; This family is most closely related to the GT1 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown ...
      PLN02949
      Location:24 → 473
      PLN02949; transferase, transferring glycosyl groups
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP06 Q9VP06

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