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    Kcmf1 Potassium channel modulatory factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41082, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcmf1provided by FlyBase
    Official Full Name
    Potassium channel modulatory factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037655
    Locus tag
    Dmel_CG11984
    See related
    AllianceGenome:FB:FBgn0037655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11984; Dmel\CG11984; kcmf1; KCMF1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in negative regulation of ERK1 and ERK2 cascade and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be active in plasma membrane. Is expressed in organism. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kcmf1 in Genome Data Viewer
    Location:
    85C2-85C2; 3-48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9010282..9014909, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4836004..4840631, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Iruka Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3b subunit 5 Neighboring gene uncharacterized protein Neighboring gene tango

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary dynamics of U12-type spliceosomal introns. Lin CF, et al. BMC Evol Biol, 2010 Feb 17. PMID 20163699, Free PMC Article
    2. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Praveen K, et al. Cell Rep, 2012 Jun 28. PMID 22813737, Free PMC Article
    3. Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways. Pessa HK, et al. PLoS One, 2010 Oct 11. PMID 20949011, Free PMC Article
    4. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. Xie J, et al. PLoS Genet, 2021 May. PMID 33983927, Free PMC Article
    5. The Deubiquitinase USP47 Stabilizes MAPK by Counteracting the Function of the N-end Rule ligase POE/UBR4 in Drosophila. Ashton-Beaucage D, et al. PLoS Biol, 2016 Aug. PMID 27552662, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel modulatory factor 1
    Names
    CG11984-PD
    CG11984-PE
    CG11984-PF
    CG11984-PG
    CG11984-PH
    CG11984-PI
    Kcmf1-PD
    Kcmf1-PE
    Kcmf1-PF
    Kcmf1-PG
    Kcmf1-PH
    Kcmf1-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9010282..9014909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169252.2 → NP_731305.2  potassium channel modulatory factor 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731305.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    2. NM_001170091.1 → NP_001163562.1  potassium channel modulatory factor 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    3. NM_001170089.1 → NP_001163560.1  potassium channel modulatory factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163560.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    4. NM_169253.2 → NP_731306.2  potassium channel modulatory factor 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731306.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    5. NM_141604.3 → NP_649861.3  potassium channel modulatory factor 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649861.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding

    6. NM_001170090.1 → NP_001163561.1  potassium channel modulatory factor 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI99, Q95RX5
      Conserved Domains (2) summary
      cd02338
      Location:7 → 55
      ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
      pfam05605
      Location:76 → 137
      zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RX5.1 Q95RX5

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