pic piccolo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: picprovided by FlyBase
Official Full Name: piccoloprovided by FlyBase
Primary source: FLYBASE:FBgn0260962
Locus tag: Dmel_CG7769
See related: AllianceGenome:FB:FBgn0260962
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0263/16; 1258/16; 1366/03; 153636_at; 263/16; CG7769; d-ddb1; D-DDB1; Dbd1; DDB-1; ddb1; Ddb1; DDB1; dDdb1; dDDB1; Dmel\CG7769; l(3)87Dh; l(3)S136603; PIC
Summary: Predicted to enable nucleic acid binding activity. Involved in several processes, including defense response to fungus; eggshell chorion gene amplification; and negative regulation of smoothened signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in nucleus and site of double-strand break. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in communication disorder. Orthologous to human DDB1 (damage specific DNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13052245..13056725)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8877967..8882447)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell chorion gene amplification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info

Names: CG7769-PA; DDB1; Damage-specific DNA binding protein 1; damaged DNA binding protein 1; drosophila damage-specific DNA-binding protein 1; pic-PA

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