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    Sema2a Semaphorin 2a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sema2aprovided by FlyBase
    Official Full Name
    Semaphorin 2aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011260
    Locus tag
    Dmel_CG4700
    See related
    AllianceGenome:FB:FBgn0011260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    112/40; BcDNA:LD09561; CG4700; CT14922; D-Sema II; D-Sema-II; D-Sema2a; D-semaII; D-SemaII; Dmel\CG4700; dSema-II; Dsema-II; l(2)03021; sema 2a; sema II; sema-2a; Sema-2a; sema-II; sema2a; semaII; SemaII
    Summary
    Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Involved in several processes, including drinking behavior; flight behavior; and neuron development. Located in cytosol and endomembrane system. Is expressed in several structures, including adult brain cell body rind; adult head; epidermis; ganglia; and gut section. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Orthologous to several human genes including SEMA3A (semaphorin 3A); SEMA3B (semaphorin 3B); and SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sema2a in Genome Data Viewer
    Location:
    53C6-53C7; 2-80 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16500178..16533459)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12387683..12420964)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 8 Neighboring gene knotted onions Neighboring gene loopin-1 Neighboring gene Syntrophin-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Axon guidance: a compelling case for repelling growth cones. Dodd J, et al. Cell, 1995 May 19. PMID 7758101
    2. Cerebral Semaphorin3D is a novel risk factor for age-associated cognitive impairment. Chen CY, et al. Cell Commun Signal, 2023 Jun 14. PMID 37316917, Free PMC Article
    3. Molecular mechanisms of proteoglycan-mediated semaphorin signaling in axon guidance. Nourisanami F, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39042673,
    4. Semaphorin II can function as a selective inhibitor of specific synaptic arborizations. Matthes DJ, et al. Cell, 1995 May 19. PMID 7758117
    5. Axon guidance. Growth cones say no. Pini A. Curr Biol, 1994 Feb 1. PMID 7953512

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PlexB is a receptor for the secreted semaphorin Sema-2a
      Title: Drosophila Plexin B is a Sema-2a receptor required for axon guidance.
    2. These data support a model in which Sema2a, while being secreted from oenocytes, represses axon extension from the sensory neuron cell body, but only in regions in direct contact with oenocytes.
      Title: Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory bulb axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory neuron axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic target inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in visual behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in endomembrane system HDA PubMed 
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    semaphorin 2a
    Names
    CG4700-PA
    CG4700-PB
    CG4700-PC
    CG4700-PE
    D-Semaphorin II
    Sema-2a
    Sema2a-PA
    Sema2a-PB
    Sema2a-PC
    Sema2a-PE
    semaphorin
    semaphorin II
    semiphorin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16500178..16533459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166178.3 → NP_725586.1  semaphorin 2a, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725586.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PTV9
      Related
      FBpp0086236
      Conserved Domains (3) summary
      cd04979
      Location:546 → 637
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
      cd11238
      Location:39 → 496
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      pfam01437
      Location:500 → 523
      PSI; Plexin repeat

    2. NM_058159.5 → NP_477507.1  semaphorin 2a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E954, Q24323, Q6NN47, Q7KRC9, Q8MLF1, Q9V7Q7
      UniProtKB/TrEMBL
      C0PTV9
      Related
      FBpp0086238
      Conserved Domains (3) summary
      cd11238
      Location:66 → 523
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      pfam01437
      Location:527 → 550
      PSI; Plexin repeat
      cd04979
      Location:573 → 668
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins

    3. NM_134303.4 → NP_599130.1  semaphorin 2a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_599130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E954, Q24323, Q6NN47, Q7KRC9, Q8MLF1, Q9V7Q7
      UniProtKB/TrEMBL
      C0PTV9
      Related
      FBpp0086237
      Conserved Domains (3) summary
      cd11238
      Location:66 → 523
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      pfam01437
      Location:527 → 550
      PSI; Plexin repeat
      cd04979
      Location:573 → 668
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins

    4. NM_206134.2 → NP_995856.2  semaphorin 2a, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995856.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E954, Q24323, Q6NN47, Q7KRC9, Q8MLF1, Q9V7Q7
      UniProtKB/TrEMBL
      C0PTV9
      Conserved Domains (3) summary
      cd11238
      Location:66 → 523
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      pfam01437
      Location:527 → 550
      PSI; Plexin repeat
      cd04979
      Location:573 → 668
      Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24323.2 Q24323

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