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    Dek Dek [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dekprovided by FlyBase
    Official Full Name
    Dekprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026533
    Locus tag
    Dmel_CG5935
    See related
    AllianceGenome:FB:FBgn0026533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0172774.191; anon-WO0172774.192; anon-WO0172774.194; CG593; CG5935; dDEK; dek; DEK; Dmel\CG5935; EG:EG0003.6; l(2)04154; l(2)k09907; lincRNA.S2954
    Summary
    Predicted to enable histone binding activity. Predicted to be involved in regulation of double-strand break repair. Located in nucleoplasm. Is expressed in adult brain cell body rind; adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to human DEK (DEK proto-oncogene). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dek in Genome Data Viewer
    Location:
    53D14-53D14; 2-80 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16856220..16861738)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12743725..12749243)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44467 Neighboring gene Integrator 8 Neighboring gene Flap endonuclease 1 Neighboring gene ncRNA Neighboring gene P-element somatic inhibitor Neighboring gene eukaryotic translation elongation factor 1 beta Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity. Kappes F, et al. Genes Dev, 2011 Apr 1. PMID 21460035, Free PMC Article
    2. REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. Gatfield D, et al. J Cell Biol, 2002 Nov 25. PMID 12438415, Free PMC Article
    3. Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. Gatfield D, et al. EMBO J, 2003 Aug 1. PMID 12881430, Free PMC Article
    4. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Karres JS, et al. Cell, 2007 Oct 5. PMID 17923093
    5. Conservation and divergence of axon guidance mechanisms. Chisholm A, et al. Curr Opin Neurobiol, 1999 Oct. PMID 10508749

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dDEK facilitated H3.3 assembly during puff formation
      Title: A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Dek
    Names
    CG5935-PA
    CG5935-PB
    CG5935-PC
    CG5935-PD
    CG5935-PE
    Dek-PA
    Dek-PB
    Dek-PC
    Dek-PD
    Dek-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16856220..16861738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274105.1 → NP_001261034.1  Dek, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261034.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAK4
      Conserved Domains (3) summary
      smart00513
      Location:282 → 316
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:64 → 144
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08766
      Location:609 → 661
      DEK_C; DEK C terminal domain

    2. NM_166198.2 → NP_725621.1  Dek, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAK3
      Related
      FBpp0099857
      Conserved Domains (3) summary
      smart00513
      Location:286 → 320
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:68 → 148
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08766
      Location:613 → 665
      DEK_C; DEK C terminal domain

    3. NM_166199.3 → NP_725622.2  Dek, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725622.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAK4
      Related
      FBpp0099855
      Conserved Domains (3) summary
      smart00513
      Location:282 → 316
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:64 → 144
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08766
      Location:609 → 661
      DEK_C; DEK C terminal domain

    4. NM_206139.3 → NP_995861.2  Dek, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995861.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IFW6
      Conserved Domains (2) summary
      smart00513
      Location:282 → 316
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:64 → 144
      RR_TM4-6; Ryanodine Receptor TM 4-6

    5. NM_143801.3 → NP_652058.1  Dek, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0D3
      Related
      FBpp0099856
      Conserved Domains (3) summary
      smart00513
      Location:288 → 322
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      pfam06459
      Location:70 → 150
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08766
      Location:615 → 667
      DEK_C; DEK C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAK3 A1ZAK3
    A1ZAK4 A1ZAK4
    O96829 O96829
    Q8IFW6 Q8IFW6
    Q8T0D3 Q8T0D3

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