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    RYBP Ring and YY1 Binding Protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RYBPprovided by FlyBase
    Official Full Name
    Ring and YY1 Binding Proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034763
    Locus tag
    Dmel_CG12190
    See related
    AllianceGenome:FB:FBgn0034763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12190; Dmel\CG12190; drybp; dRYBP; rybp; Rybp
    Summary
    Enables DNA binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of apoptotic process; and negative regulation of immune response. Located in nuclear body. Is expressed in several structures, including adult fat body; larval imaginal tissue; and oocyte. Orthologous to several human genes including YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RYBP in Genome Data Viewer
    Location:
    58F7-58F7; 2-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22670587..22673212)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18558092..18560717)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45269 Neighboring gene long non-coding RNA:CR42868 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44761 Neighboring gene Partner of paired Neighboring gene long non-coding RNA:CR44762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YY1 DNA binding and interaction with YAF2 is essential for Polycomb recruitment. Basu A, et al. Nucleic Acids Res, 2014 Feb. PMID 24285299, Free PMC Article
    2. A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila. Fereres S, et al. Apoptosis, 2013 Dec. PMID 23979704
    3. The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor. Bejarano F, et al. Mech Dev, 2005 Oct. PMID 16125914
    4. PcG recruitment by the YY1 REPO domain can be mediated by Yaf2. Wilkinson F, et al. J Cell Biochem, 2010 Feb 15. PMID 19960508, Free PMC Article
    5. Drosophila SCE/dRING E3-ligase inhibits apoptosis in a Dp53 dependent manner. Simoes da Silva CJ, et al. Dev Biol, 2017 Sep 1. PMID 28712876

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data how that dRYBP protein is itself ubiquitylated and binds ubiquitylated proteins.
      Title: dRYBP counteracts chromatin-dependent activation and repression of transcription.
    2. dRYBP-SCF complex inhibit apoptosis in Drosophila.
      Title: A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila.
    3. RYBP-induced apoptosis is inhibited by high levels of either p35 or Drosophila Inhibitor of Apoptosis Protein 1, and requires the function of the pro-apoptotic REAPER protein.
      Title: High levels of dRYBP induce apoptosis in Drosophila imaginal cells through the activation of reaper and the requirement of trithorax, dredd and dFADD.
    4. These results indicate that the dRYBP gene functions in the control of cell identity together with the Sex comb extra gene/trithorax gene proteins.
      Title: Functional characterization of the dRYBP gene in Drosophila.
    5. The Ring and YY1 Binding Protein (RYBP) is able to interact with Polycomb group proteins to repress transcription.
      Title: The Drosophila RYBP gene functions as a Polycomb-dependent transcriptional repressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ring and YY1 binding protein
    Names
    CG12190-PA
    CG12190-PB
    RYBP-PA
    RYBP-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22670587..22673212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299813.1 → NP_001286742.1  ring and YY1 binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T097, Q9W215
      Conserved Domains (2) summary
      sd00030
      Location:23 → 42
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:20 → 43
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. NM_137861.3 → NP_611705.1  ring and YY1 binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T097, Q9W215
      Related
      FBpp0071779
      Conserved Domains (2) summary
      sd00030
      Location:23 → 42
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:20 → 43
      zf-RanBP; Zn-finger in Ran binding protein and others
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W215 Q9W215

    Gene LinkOut

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