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    TwdlF TweedleF [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40534, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TwdlFprovided by FlyBase
    Official Full Name
    TweedleFprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037224
    Locus tag
    Dmel_CG14639
    See related
    AllianceGenome:FB:FBgn0037224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14639; Dmel\CG14639
    Summary
    A structural constituent of chitin-based larval cuticle. Involved in chitin-based cuticle development. Located in chitin-based extracellular matrix. Is expressed in embryonic dorsal epidermis; embryonic head epidermis; and embryonic ventral epidermis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TwdlF in Genome Data Viewer
    Location:
    82A1-82A1; 3-47.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4247020..4248313)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (72742..74035)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TweedleU Neighboring gene TweedleG Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression patterns of cardiac aging in Drosophila. Cannon L, et al. Aging Cell, 2017 Feb. PMID 28090760, Free PMC Article
    2. Inhibition of fatty acid desaturation impairs cuticle differentiation in Drosophila melanogaster. Wang Y, et al. Arch Insect Biochem Physiol, 2019 Apr. PMID 30672604
    3. Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila. Guan X, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075064, Free PMC Article
    4. δ-Aminolevulinate synthase is required for apical transcellular barrier formation in the skin of the Drosophila larva. Shaik KS, et al. Eur J Cell Biol, 2012 Mar. PMID 22293958
    5. Tweedle proteins form extracellular two-dimensional structures defining body and cell shape in Drosophila melanogaster. Zuber R, et al. Open Biol, 2020 Dec. PMID 33292106, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TweedleF
    Names
    CG14639-PA
    TwdlF-PA
    tweedle

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4247020..4248313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141186.4 → NP_649443.1  TweedleF [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649443.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMZ5
      Related
      FBpp0078614
      Conserved Domains (1) summary
      smart00690
      Location:137 → 241
      DM5; Domain of unknown function, currently peculiar to Drosophila
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMZ5 Q9VMZ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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