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    Idgf6 Imaginal disc growth factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36868, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idgf6provided by FlyBase
    Official Full Name
    Imaginal disc growth factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0013763
    Locus tag
    Dmel_CG5210
    See related
    AllianceGenome:FB:FBgn0013763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5210; chit; Chit; Chit13; Cht13; DmDS47; Dmel\CG5210; DmIDGF6; ds47; DS47; idgf6
    Summary
    Enables chitin binding activity. Involved in several processes, including ecdysis, chitin-based cuticle; regulation of chitin metabolic process; and regulation of tube architecture, open tracheal system. Located in extracellular space. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1); CHI3L1 (chitinase 3 like 1); and CHI3L2 (chitinase 3 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Idgf6 in Genome Data Viewer
    Location:
    53D2-53D2; 2-80 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16691022..16693751)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12578527..12581256)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Polypeptide N-Acetylgalactosaminyltransferase 9 Neighboring gene long non-coding RNA:CR43104 Neighboring gene long non-coding RNA:CR44464

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages. Kirkpatrick RB, et al. Gene, 1995 Feb 14. PMID 7875581
    2. A new family of growth factors produced by the fat body and active on Drosophila imaginal disc cells. Kawamura K, et al. Development, 1999 Jan. PMID 9847235
    3. Imaginal disk growth factors are Drosophila chitinase-like proteins with roles in morphogenesis and CO2 response. Sustar AE, et al. Genetics, 2023 Feb 9. PMID 36576887, Free PMC Article
    4. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
    5. Proteomics Analysis Identifies Orthologs of Human Chitinase-Like Proteins as Inducers of Tube Morphogenesis Defects in Drosophila melanogaster. Zimmerman SG, et al. Genetics, 2017 Jun. PMID 28404605, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables chitinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables imaginal disc growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of chitin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube architecture, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    imaginal disc growth factor 6
    Names
    CG5210-PA
    CG5210-PB
    Idgf6-PA
    Idgf6-PB
    chitinase-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16691022..16693751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299570.1 → NP_001286499.1  imaginal disc growth factor 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286499.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVC8, E1UIC7, E1UIC9, E1UID0, E1UID3, E1UID4, Q23997, Q9V7S9
      UniProtKB/TrEMBL
      A0A0B4LFJ1
      Conserved Domains (2) summary
      cd02873
      Location:30 → 450
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:31 → 429
      Glyco_18; Glyco_18 domain

    2. NM_057733.4 → NP_477081.1  imaginal disc growth factor 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A2RVC8, E1UIC7, E1UIC9, E1UID0, E1UID3, E1UID4, Q23997, Q9V7S9
      UniProtKB/TrEMBL
      A0A0B4LFJ1
      Related
      FBpp0086257
      Conserved Domains (2) summary
      cd02873
      Location:30 → 450
      GH18_IDGF; The IDGF's (imaginal disc growth factors) are a family of growth factors identified in insects that include at least five members, some of which are encoded by genes in a tight cluster. The IDGF's have an eight-stranded alpha/beta barrel fold and are ...
      smart00636
      Location:31 → 429
      Glyco_18; Glyco_18 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFJ1 A0A0B4LFJ1
    Q23997.2 Q23997

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