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    eEF1beta eukaryotic translation elongation factor 1 beta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eEF1betaprovided by FlyBase
    Official Full Name
    eukaryotic translation elongation factor 1 betaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028737
    Locus tag
    Dmel_CG6341
    See related
    AllianceGenome:FB:FBgn0028737
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    154264_at; BcDNA.LD24492; BcDNA:LD24492; CG6341; Dmel\CG6341; Ef1beta; EG:EG0003.7; Elf 1 beta
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eEF1beta in Genome Data Viewer
    Location:
    53D14-53D14; 2-80 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16868222..16869280)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12755727..12756785)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Dek Neighboring gene P-element somatic inhibitor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An enhancer trap screen for ecdysone-inducible genes required for Drosophila adult leg morphogenesis. Gates J, et al. Genetics, 2000 Dec. PMID 11102372, Free PMC Article
    2. Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. Boyle MJ, et al. Dev Biol, 2010 Oct 1. PMID 20659448, Free PMC Article
    3. Over-expression of a novel nuclear interactor of Suppressor of fused, the Drosophila myelodysplasia/myeloid leukaemia factor, induces abnormal morphogenesis associated with increased apoptosis and DNA synthesis. Fouix S, et al. Genes Cells, 2003 Nov. PMID 14622141
    4. Bam-dependent deubiquitinase complex can disrupt germ-line stem cell maintenance by targeting cyclin A. Ji S, et al. Proc Natl Acad Sci U S A, 2017 Jun 13. PMID 28484036, Free PMC Article
    5. Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function. Costello JC, et al. Genome Biol, 2009. PMID 19758432, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation elongation factor 1 beta
    Names
    CG6341-PB
    CG6341-PC
    eEF1beta-PB
    eEF1beta-PC
    elongation facto 1 beta
    elongation factor 1 beta
    elongation factor 1beta

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16868222..16869280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299577.1 → NP_001286506.1  eukaryotic translation elongation factor 1 beta, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96827
      UniProtKB/TrEMBL
      A0A0B4LFL3
      Conserved Domains (2) summary
      cd10308
      Location:3 → 62
      GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
      pfam00736
      Location:139 → 222
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    2. NM_080069.4 → NP_524808.3  eukaryotic translation elongation factor 1 beta, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524808.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96827
      UniProtKB/TrEMBL
      A0A0B4LFL3
      Conserved Domains (2) summary
      cd10308
      Location:3 → 62
      GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
      pfam00736
      Location:139 → 222
      EF1_GNE; EF-1 guanine nucleotide exchange domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFL3 A0A0B4LFL3
    O96827.3 O96827

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