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    CG11241 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40492, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11241provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037186
    Locus tag
    Dmel_CG11241
    See related
    AllianceGenome:FB:FBgn0037186
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11241
    Summary
    Predicted to enable alanine-glyoxylate transaminase activity. Predicted to be involved in L-alanine catabolic process, by transamination and glyoxylate catabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; epithelial tube; gut section; and mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); atrial fibrillation; cerebral infarction; congestive heart failure; and mild cognitive impairment. Orthologous to human AGXT2 (alanine--glyoxylate aminotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11241 in Genome Data Viewer
    Location:
    80A1-80A1; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22732013..22738420, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22726252..22731520, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene maelstrom Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45163 Neighboring gene lethal (3) 04053 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nutritional geometry framework of sleep. Lai ML, et al. Life Sci, 2023 Mar 1. PMID 36640899
    2. Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases. Southall TD, et al. Physiol Genomics, 2006 Jun 16. PMID 16609144
    3. Serine metabolism in the brain regulates starvation-induced sleep suppression in Drosophila melanogaster. Sonn JY, et al. Proc Natl Acad Sci U S A, 2018 Jul 3. PMID 29915051, Free PMC Article
    4. Functional correlates of positional and gender-specific renal asymmetry in Drosophila. Chintapalli VR, et al. PLoS One, 2012. PMID 22496733, Free PMC Article
    5. A genome-wide RNAi screen reveals multiple regulators of caspase activation. Yi CH, et al. J Cell Biol, 2007 Nov 19. PMID 17998402, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alanine-glyoxylate transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-glyoxylate transaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-alanine catabolic process, by transamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glyoxylate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11241-PA
    CG11241-PB
    CG11241-PC
    NP_001303389.1
    NP_649413.3
    NP_730741.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22732013..22738420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316460.1 → NP_001303389.1  uncharacterized protein Dmel_CG11241, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E6R2, Q95TT3
      Conserved Domains (2) summary
      cd00610
      Location:80 → 500
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:55 → 501
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    2. NM_168960.4 → NP_730741.2  uncharacterized protein Dmel_CG11241, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730741.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E6R2, Q95TT3
      Conserved Domains (2) summary
      cd00610
      Location:80 → 500
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:55 → 501
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    3. NM_141156.4 → NP_649413.3  uncharacterized protein Dmel_CG11241, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649413.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TT3, Q9VNR7
      Related
      FBpp0078188
      Conserved Domains (2) summary
      cd00610
      Location:80 → 500
      OAT_like; Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase, ...
      COG0160
      Location:55 → 504
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8E6R2 A8E6R2
    Q95TT3 Q95TT3
    Q9VNR7 Q9VNR7

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