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    Nt5a 5' nucleotidase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nt5aprovided by FlyBase
    Official Full Name
    5' nucleotidase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035204
    Locus tag
    Dmel_CG2277
    See related
    AllianceGenome:FB:FBgn0035204
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    28575006; CG2277; Dmel\CG2277; dNT5A
    Summary
    Predicted to enable 5'-nucleotidase activity. Is expressed in organism. Orthologous to human NT5DC1 (5'-nucleotidase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nt5a in Genome Data Viewer
    Location:
    61F5-61F5; 3-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1304850..1307418, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1304850..1307418, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rac1 Neighboring gene Acetyl-CoA acetyltransferase 2 Neighboring gene Ctr9 Neighboring gene sturkopf Neighboring gene HECT and RLD domain containing E3 ubiquitin ligase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). Singgih EL, et al. Transl Psychiatry, 2021 Jan 18. PMID 33462198, Free PMC Article
    2. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. Litovchenko M, et al. Sci Adv, 2021 Jan. PMID 33514540, Free PMC Article
    3. The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy. Pogson JH, et al. PLoS Genet, 2014 Nov. PMID 25412178, Free PMC Article
    4. A gain-of-function screen for genes that influence axon guidance identifies the NF-kappaB protein dorsal and reveals a requirement for the kinase Pelle in Drosophila photoreceptor axon targeting. Mindorff EN, et al. Genetics, 2007 Aug. PMID 17603113, Free PMC Article
    5. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Blanco E, et al. Genome Biol, 2008. PMID 18783608, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    5' nucleotidase A
    Names
    CG2277-PA
    CG2277-PB
    CG2277-PC
    Nt5a-PA
    Nt5a-PB
    Nt5a-PC
    NP_001261248.1
    NP_001286897.1
    NP_612095.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1304850..1307418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274319.1 → NP_001261248.1  5' nucleotidase A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261248.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961B3, Q9W0H5
      Conserved Domains (1) summary
      TIGR02244
      Location:101 → 466
      HAD-IG-Ncltidse; HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase

    2. NM_138251.3 → NP_612095.3  5' nucleotidase A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612095.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961B3, Q9W0H5
      Related
      FBpp0072613
      Conserved Domains (1) summary
      TIGR02244
      Location:101 → 466
      HAD-IG-Ncltidse; HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase

    3. NM_001299968.1 → NP_001286897.1  5' nucleotidase A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCB6
      Conserved Domains (1) summary
      cl17687
      Location:2 → 367
      5_nucleotid; 5' nucleotidase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961B3 Q961B3
    X2JCB6 X2JCB6

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