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    Smyd4-1 SET and MYND domain containing, class 4, member 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35985, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smyd4-1provided by FlyBase
    Official Full Name
    SET and MYND domain containing, class 4, member 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033427
    Locus tag
    Dmel_CG1868
    See related
    AllianceGenome:FB:FBgn0033427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1868; Dmel\CG1868
    Summary
    Predicted to enable histone H3K4 methyltransferase activity and histone deacetylase binding activity. Involved in compound eye photoreceptor development. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic/larval gut; larval central nervous system; larval somatic muscle cell; midgut primordium; and procephalic segment. Orthologous to human SMYD4 (SET and MYND domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Smyd4-1 in Genome Data Viewer
    Location:
    45F4-45F5; 2-61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9581761..9584545, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5469266..5472050, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45281 Neighboring gene Alkaline phosphatase 6 Neighboring gene Not1 Neighboring gene long non-coding RNA:CR46257 Neighboring gene 5' nucleotidase C Neighboring gene uncharacterized protein Neighboring gene Uroporphyrinogen decarboxylase Neighboring gene Ribosomal protein L31 Neighboring gene closca

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary History of the Smyd Gene Family in Metazoans: A Framework to Identify the Orthologs of Human Smyd Genes in Drosophila and Other Animal Species. Calpena E, et al. PLoS One, 2015. PMID 26230726, Free PMC Article
    2. A Drosophila Smyd4 homologue is a muscle-specific transcriptional modulator involved in development. Thompson EC, et al. PLoS One, 2008 Aug 20. PMID 18714374, Free PMC Article
    3. Comparative genomic analysis of SET domain family reveals the origin, expansion, and putative function of the arthropod-specific SmydA genes as histone modifiers in insects. Jiang F, et al. Gigascience, 2017 Jun 1. PMID 28444351, Free PMC Article
    4. A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Schotta G, et al. Genes Dev, 2004 Jun 1. PMID 15145825, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone H3K4 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SET and MYND domain containing, class 4, member 1
    Names
    CG1868-PB
    CG1868-PC
    Smyd4-1-PB
    Smyd4-1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9581761..9584545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165681.2 → NP_724802.1  SET and MYND domain containing, class 4, member 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7W1, Q5U0T5
      Related
      FBpp0087625
      Conserved Domains (2) summary
      smart00317
      Location:447 → 526
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam01753
      Location:258 → 298
      zf-MYND; MYND finger

    2. NM_136656.3 → NP_610500.2  SET and MYND domain containing, class 4, member 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610500.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7W1, Q5U0T5
      Conserved Domains (2) summary
      smart00317
      Location:447 → 526
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam01753
      Location:258 → 298
      zf-MYND; MYND finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7W1 A1Z7W1
    Q7K4R6 Q7K4R6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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