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    IntS9 Integrator 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39763, updated on 9-Dec-2024

    Summary

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    Official Symbol
    IntS9provided by FlyBase
    Official Full Name
    Integrator 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0036570
    Locus tag
    Dmel_CG5222
    See related
    AllianceGenome:FB:FBgn0036570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5222; Dmel\CG5222; Int9; Ints9
    Summary
    Involved in negative regulation of BMP signaling pathway and snRNA 3'-end processing. Located in cytosol and nucleus. Orthologous to human INTS9 (integrator complex subunit 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See IntS9 in Genome Data Viewer
    Location:
    72D6-72D6; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16103432..16105627, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16096532..16098727, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Chloride channel-c Neighboring gene uncharacterized protein Neighboring gene ATP synthase, beta subunit-like Neighboring gene Isoleucyl-tRNA synthetase, mitochondrial Neighboring gene uncharacterized protein Neighboring gene Zinc-finger protein at 72D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes. Elrod ND, et al. Mol Cell, 2019 Dec 5. PMID 31809743, Free PMC Article
    2. Inositol hexakisphosphate is required for Integrator function. Lin MH, et al. Nat Commun, 2022 Sep 30. PMID 36180473, Free PMC Article
    3. Antisense oligonucleotide technology can be used to investigate a circular but not linear RNA-mediated function for its encoded gene locus. Song Z, et al. Sci China Life Sci, 2021 May. PMID 32815066
    4. Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex. Chen J, et al. J Biol Chem, 2013 Feb 15. PMID 23288851, Free PMC Article
    5. Attenuation of Eukaryotic Protein-Coding Gene Expression via Premature Transcription Termination. Tatomer DC, et al. Cold Spring Harb Symp Quant Biol, 2019. PMID 32086332

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator 9
    Names
    CG5222-PA
    IntS9-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16103432..16105627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140581.4 → NP_648838.3  integrator 9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648838.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TS5, Q9VUY5
      Related
      FBpp0075250
      Conserved Domains (2) summary
      smart01027
      Location:304 → 428
      Beta-Casp; Beta-Casp domain
      cl23716
      Location:1 → 264
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TS5.1 Q95TS5

    Gene LinkOut

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