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    140up upstream of RpII140 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    140upprovided by FlyBase
    Official Full Name
    upstream of RpII140provided by FlyBase
    Primary source
    FLYBASE:FBgn0010340
    Locus tag
    Dmel_CG9852
    See related
    AllianceGenome:FB:FBgn0010340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9852; Dmel\CG9852; DmRP140-upstream; DmRP140up; dTIMMDC1; l(3)88Ba; l(3)Z6
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval midgut; larval visceral muscle cell; and organism. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 31. Orthologous to human TIMMDC1 (translocase of inner mitochondrial membrane domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See 140up in Genome Data Viewer
    Location:
    88A9-88A9; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14124163..14125548, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9949885..9951270, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kinesin family member 19A Neighboring gene Abelson interacting protein Neighboring gene twinfilin Neighboring gene RNA polymerase II subunit B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription of DmRP140, the gene coding for the second-largest subunit of RNA polymerase II. Wiedemann M, et al. Biochim Biophys Acta, 1997 Feb 28. PMID 9061024
    2. Analysis of the promoter region of the housekeeping gene DmRP140 by sequence comparison of Drosophila melanogaster and Drosophila virilis. Sitzler S, et al. Gene, 1991 Apr. PMID 1905256
    3. Twinfilin is required for actin-dependent developmental processes in Drosophila. Wahlström G, et al. J Cell Biol, 2001 Nov 26. PMID 11724820, Free PMC Article
    4. Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit. Hamilton BJ, et al. Genetics, 1993 Jun. PMID 8325487, Free PMC Article
    5. Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila. Breen TR, et al. Mech Dev, 1991 Sep. PMID 1684714

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    upstream of RpII140
    Names
    140up-PA
    140up-PB
    CG9852-PA
    CG9852-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14124163..14125548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275632.1 → NP_001262561.1  upstream of RpII140, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262561.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81928, Q9VFM8
      UniProtKB/TrEMBL
      A0A0B4KFZ0
      Conserved Domains (1) summary
      pfam02466
      Location:67 → 179
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_057603.6 → NP_476951.1  upstream of RpII140, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476951.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P81928, Q9VFM8
      UniProtKB/TrEMBL
      A0A0B4KFZ0
      Related
      FBpp0082370
      Conserved Domains (1) summary
      pfam02466
      Location:67 → 179
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ0 A0A0B4KFZ0
    P81928.2 P81928

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