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    rin rasputin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47998, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rinprovided by FlyBase
    Official Full Name
    rasputinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015778
    Locus tag
    Dmel_CG9412
    See related
    AllianceGenome:FB:FBgn0015778
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg9412; CG9412; Dmel\CG9412; Nts; rasp; Rin; RIN
    Summary
    Predicted to enable DNA helicase activity; RNA helicase activity; and mRNA binding activity. Involved in several processes, including compound eye morphogenesis; dorsal/ventral axis specification, ovarian follicular epithelium; and stress granule assembly. Located in cytoplasmic stress granule and cytosol. Part of ribonucleoprotein complex. Is expressed in several structures, including adult head; eye disc; female germline cyst; follicle cell; and ovary. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1) and G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rin in Genome Data Viewer
    Location:
    87F6-87F7; 3-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13647004..13654527)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9472726..9480249)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene squid Neighboring gene RNA-binding protein 4 Neighboring gene Heterogeneous nuclear ribonucleoprotein at 87F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detecting Stress Granules in Drosophila Neurons. De Graeve F, et al. Methods Mol Biol, 2022. PMID 35171483
    2. Disruption of Stress Granule Formation by the Multifunctional Cricket Paralysis Virus 1A Protein. Khong A, et al. J Virol, 2017 Mar 1. PMID 28003491, Free PMC Article
    3. Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster. Vognsen T, et al. Biochem Biophys Res Commun, 2012 Mar 30. PMID 22414690
    4. Rasputin, more promiscuous than ever: a review of G3BP. Irvine K, et al. Int J Dev Biol, 2004 Dec. PMID 15602692
    5. The transcriptional response to oxidative stress is independent of stress-granule formation. Singh A, et al. Mol Biol Cell, 2022 Mar 1. PMID 34985933, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.
      Title: The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs.
    2. Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
      Title: Rasputin functions as a positive regulator of orb in Drosophila oogenesis.
    3. Lig regulates cell proliferation during development in concert with Rin, Capr and FMR1.
      Title: The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.
    4. The crystal structure of the NTF2-like domain of the Drosophila homolog of Ras GTPase SH3 Binding Protein (G3BP), Rasputin, was determined at 2.7A resolution.
      Title: Crystal structure of the Rasputin NTF2-like domain from Drosophila melanogaster.
    5. G3BPs are scaffolding proteins linking signal transduction to RNA metabolism (review)
      Title: Rasputin, more promiscuous than ever: a review of G3BP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in compound eye photoreceptor fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification, ovarian follicular epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification, ovarian follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ommatidial rotation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in stress granule assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of ribonucleoprotein complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rasputin
    Names
    CG9412-PB
    CG9412-PE
    CG9412-PF
    CG9412-PG
    next to squid
    rin-PB
    rin-PE
    rin-PF
    rin-PG
    NP_524907.2
    NP_731828.1
    NP_731829.1
    NP_731830.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13647004..13654527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169533.2 → NP_731830.2  rasputin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731830.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7J5, Q9NH72, Q9VFT4
      Related
      FBpp0312064
      Conserved Domains (3) summary
      COG0724
      Location:423 → 557
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:12 → 131
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12229
      Location:490 → 580
      RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

    2. NM_169532.2 → NP_731829.1  rasputin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7J5, Q9NH72, Q9VFT4
      Related
      FBpp0082267
      Conserved Domains (3) summary
      COG0724
      Location:423 → 557
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:12 → 131
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12229
      Location:490 → 580
      RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

    3. NM_080168.3 → NP_524907.2  rasputin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524907.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7J5, Q9NH72, Q9VFT4
      Related
      FBpp0082265
      Conserved Domains (3) summary
      COG0724
      Location:423 → 557
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:12 → 131
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12229
      Location:490 → 580
      RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins

    4. NM_169531.2 → NP_731828.1  rasputin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731828.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9I7J5, Q9NH72, Q9VFT4
      Related
      FBpp0312063
      Conserved Domains (3) summary
      COG0724
      Location:423 → 557
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00780
      Location:12 → 131
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
      cd12229
      Location:490 → 580
      RRM_G3BP; RNA recognition motif (RRM) in ras GTPase-activating protein-binding protein G3BP1, G3BP2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NH72 Q9NH72
    Q9VFT4 Q9VFT4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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