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    mei-S332 meiotic from via Salaria 332 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37523, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mei-S332provided by FlyBase
    Official Full Name
    meiotic from via Salaria 332provided by FlyBase
    Primary source
    FLYBASE:FBgn0002715
    Locus tag
    Dmel_CG5303
    See related
    AllianceGenome:FB:FBgn0002715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD13774; CG5303; Dmel\CG5303; mei-S322; MEI-S322; mei-s332; Mei-S332; MEI-S332; Mei-S332/Shugoshin; meiS322; meiS332; MeiS332
    Summary
    Involved in male meiosis sister chromatid cohesion and meiotic nuclear division. Located in condensed chromosome, centromeric region and pericentric heterochromatin. Is expressed in several structures, including embryonic brain; gonad; larval nervous system; pole plasm; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mei-S332 in Genome Data Viewer
    Location:
    58B9-58B10; 2-98 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22122101..22124566)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18009606..18012071)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Verprolin 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Golgi matrix protein 130 kD Neighboring gene NtR Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The influence of chromosome content on the size and shape of sperm heads in Drosophila melanogaster and the demonstration of chromosome loss during spermiogenesis. Hardy RW. Genetics, 1975 Feb. PMID 805747, Free PMC Article
    2. Meiosis: Rec8 is the reason for cohesion. Stoop-Myer C, et al. Nat Cell Biol, 1999 Sep. PMID 10559953
    3. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein. Tang TT, et al. Genes Dev, 1998 Dec 15. PMID 9869638, Free PMC Article
    4. The cohesion protein MEI-S332 localizes to condensed meiotic and mitotic centromeres until sister chromatids separate. Moore DP, et al. J Cell Biol, 1998 Mar 9. PMID 9490715, Free PMC Article
    5. The mitotic centromeric protein MEI-S332 and its role in sister-chromatid cohesion. LeBlanc HN, et al. Chromosoma, 1999 Dec. PMID 10654079

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wdb and Wrd contribute to MEI-S332's ability to ensure accurate segregation of sister chromatids but in centromere localization, they do not act solely downstream of MEI-S332.
      Title: Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.
    2. INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
      Title: INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis sister chromatid cohesion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meiotic from via salaria 332
    Names
    CG5303-PA
    CG5303-PB
    Mei-S332
    MeiS332
    mei-S332-PA
    mei-S332-PB
    meiotic from salaria 332
    shugoshin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22122101..22124566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057286.5 → NP_476634.1  meiotic from via salaria 332, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476634.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24141
      UniProtKB/TrEMBL
      A0A0B4LG47
      Related
      FBpp0071675
      Conserved Domains (2) summary
      pfam07558
      Location:5 → 49
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
      pfam13874
      Location:15 → 102
      Nup54; Nucleoporin complex subunit 54

    2. NM_001299776.1 → NP_001286705.1  meiotic from via salaria 332, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24141
      UniProtKB/TrEMBL
      A0A0B4LG47
      Conserved Domains (2) summary
      pfam07558
      Location:5 → 49
      Shugoshin_N; Shugoshin N-terminal coiled-coil region
      pfam13874
      Location:15 → 102
      Nup54; Nucleoporin complex subunit 54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LG47 A0A0B4LG47
    Q24141.1 Q24141

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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