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    CG31650 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG31650provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031673
    Locus tag
    Dmel_CG31650
    See related
    AllianceGenome:FB:FBgn0031673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9112; Dmel\CG31650; RCN2
    Summary
    Predicted to enable calcium ion binding activity. Located in endoplasmic reticulum. Is expressed in several structures, including central brain primordium; ganglia; larval nervous system; ventral midline of embryo; and ventral nerve cord primordium. Orthologous to human RCN2 (reticulocalbin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG31650 in Genome Data Viewer
    Location:
    25C1-25C1; 2-15 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5040648..5044712, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5040648..5044712, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene viking Neighboring gene Collagen type IV alpha 1 Neighboring gene uncharacterized protein Neighboring gene SP555 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit h Neighboring gene senju

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis. Balasubramanian V, et al. Genome, 2020 Feb. PMID 31557446
    2. Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model. Gilbert R, et al. NPJ Microgravity, 2020. PMID 32047838, Free PMC Article
    3. Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion. Hornbruch-Freitag C, et al. J Cell Sci, 2011 Oct 1. PMID 21896648
    4. Molecular organization of Drosophila neuroendocrine cells by Dimmed. Park D, et al. Curr Biol, 2011 Sep 27. PMID 21885285, Free PMC Article
    5. Identification of ER proteins involved in the functional organisation of the early secretory pathway in Drosophila cells by a targeted RNAi screen. Kondylis V, et al. PLoS One, 2011 Feb 23. PMID 21383842, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG31650-PA
    CG31650-PB
    CG31650-PC
    CG31650-PD
    CG31650-PE
    CG31650-PF
    CG31650-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5040648..5044712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169410.1 → NP_001162881.1  uncharacterized protein Dmel_CG31650, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_164619.2 → NP_723048.1  uncharacterized protein Dmel_CG31650, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Related
      FBpp0078669
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001169409.1 → NP_001162880.1  uncharacterized protein Dmel_CG31650, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    4. NM_001273146.1 → NP_001260075.1  uncharacterized protein Dmel_CG31650, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260075.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PC74
      Conserved Domains (2) summary
      pfam13499
      Location:181 → 238
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:181 → 238
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    5. NM_135055.4 → NP_608899.1  uncharacterized protein Dmel_CG31650, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608899.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Related
      FBpp0078671
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    6. NM_001169408.1 → NP_001162879.1  uncharacterized protein Dmel_CG31650, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    7. NM_164620.2 → NP_723049.1  uncharacterized protein Dmel_CG31650, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723049.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1W8
      Related
      FBpp0078670
      Conserved Domains (2) summary
      pfam13499
      Location:184 → 241
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:100 → 153
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC74 M9PC74
    Q7K1W8 Q7K1W8

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