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    EndoG Endonuclease G [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36309, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EndoGprovided by FlyBase
    Official Full Name
    Endonuclease Gprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033690
    Locus tag
    Dmel_CG8862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8862; dEndoG; Dmel\CG8862; endoG; ENDOG
    Orthologs
    all
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    Genomic context

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    See EndoG in Genome Data Viewer
    Location:
    48E4-48E4; 2-66 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12177430..12178553, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8064935..8066058, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Ornithine decarboxylase antizyme Neighboring gene antisense RNA:CR46194 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop Neighboring gene Chaperonin containing TCP1 subunit 5 Neighboring gene antisense RNA:CR45264 Neighboring gene uncharacterized protein Neighboring gene washout

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular inhibitor of apoptosis protein 1 ubiquitinates endonuclease G but does not affect endonuclease G-mediated cell death. Seo TW, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25139236
    2. The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. Temme C, et al. J Biol Chem, 2009 Mar 27. PMID 19129189, Free PMC Article
    3. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573, Free PMC Article
    4. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208
    5. The Release 6 reference sequence of the Drosophila melanogaster genome. Hoskins RA, et al. Genome Res, 2015 Mar. PMID 25589440, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    endonuclease G
    Names
    CG8862-PA
    EndoG-PA
    NP_610737.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12177430..12178553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136893.4 → NP_610737.1  endonuclease G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610737.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JXB9
      Related
      FBpp0087120
      Conserved Domains (2) summary
      COG1864
      Location:39 → 305
      NUC1; DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]
      cd00091
      Location:77 → 309
      NUC; DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JXB9 Q7JXB9

    Gene LinkOut

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