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    CG8032 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41026, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8032provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037606
    Locus tag
    Dmel_CG8032
    See related
    AllianceGenome:FB:FBgn0037606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8032; PAOX
    Summary
    Predicted to enable polyamine oxidase activity. Predicted to be active in cytoplasm. Is expressed in organism. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to several human genes including PAOX (polyamine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8032 in Genome Data Viewer
    Location:
    85A5-85A5; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8664115..8667772)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4489837..4493494)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sys1 golgi trafficking protein Neighboring gene uncharacterized protein Neighboring gene belle Neighboring gene pink Neighboring gene transfer RNA:Tyrosine-GTA 1-6 Neighboring gene transfer RNA:Tyrosine-GTA 1-7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene. Syrzycka M, et al. Genome, 2007 Jun. PMID 17632576
    2. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
    3. Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism. Islam A, et al. Metabolites, 2023 May 9. PMID 37233683, Free PMC Article
    4. A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster. Nakayama M, et al. BMC Genet, 2014 Apr 16. PMID 24739137, Free PMC Article
    5. Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. Greene JC, et al. Hum Mol Genet, 2005 Mar 15. PMID 15689351

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8032-PA
    CG8032-PB
    NP_001262380.1
    NP_649811.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8664115..8667772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275451.2 → NP_001262380.1  uncharacterized protein Dmel_CG8032, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN8
      Conserved Domains (2) summary
      pfam01593
      Location:49 → 556
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:44 → 104
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    2. NM_141554.3 → NP_649811.1  uncharacterized protein Dmel_CG8032, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHN8
      Related
      FBpp0081369
      Conserved Domains (2) summary
      pfam01593
      Location:49 → 556
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:44 → 104
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHN8 Q9VHN8

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