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    Axn Axin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43565, updated on 9-Dec-2024

    Summary

    Official Symbol
    Axnprovided by FlyBase
    Official Full Name
    Axinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026597
    Locus tag
    Dmel_CG7926
    See related
    AllianceGenome:FB:FBgn0026597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0442/30; APC; axin; axn; CG7926; d-axin; D-Axin; dAxin; dAXIN; Daxin; DAxin; din; Dmel\CG7926; GS; GSK3beta; l(3)S044230
    Summary
    Enables several functions, including beta-catenin binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in several processes, including instar larval or pupal development; negative regulation of canonical Wnt signaling pathway; and regionalization. Located in cytoplasm; nucleus; and plasma membrane. Part of Wnt signalosome and beta-catenin destruction complex. Is active in cytosol. Used to study cancer. Human ortholog(s) of this gene implicated in endometrial adenocarcinoma; gastrointestinal system cancer (multiple); lung cancer (multiple); orofacial cleft; and urinary bladder cancer. Orthologous to human AXIN1 (axin 1) and AXIN2 (axin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Axn in Genome Data Viewer
    Location:
    99D2-99D3; 3-100 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30022842..30035311)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25848564..25861033)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Neighboring gene Ribosomal protein S28a Neighboring gene long non-coding RNA:CR46111 Neighboring gene antisense RNA:CR44045 Neighboring gene Zinc-finger protein interacting with CP190 Neighboring gene ocnus Neighboring gene janus B Neighboring gene janus A

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables molecular adaptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chitin-based larval cuticle pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye-antennal disc morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing margin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of execution phase of apoptosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in segment polarity determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Wnt signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of beta-catenin destruction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    axin
    Names
    Axn-PA
    Axn-PB
    Axn-PC
    Axn-PD
    Axn-PE
    Axn-PF
    Axn-PG
    CG7926-PA
    CG7926-PB
    CG7926-PC
    CG7926-PD
    CG7926-PE
    CG7926-PF
    CG7926-PG
    D-axin
    Dm axin
    axn
    dAxin
    glycogen synthase kinase 3beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30022842..30035311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170457.3NP_733336.1  axin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V407, Q9XYC1
      UniProtKB/TrEMBL
      A4V3M5, C3KGN7
      Related
      FBpp0084919
      Conserved Domains (3) summary
      pfam00778
      Location:665739
      DIX; DIX domain
      pfam08833
      Location:494543
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001144654.3NP_001138126.1  axin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001138126.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z0S0, C3KGN7
      Conserved Domains (3) summary
      pfam00778
      Location:619693
      DIX; DIX domain
      pfam08833
      Location:448497
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_001276168.1NP_001263097.1  axin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHW0, C3KGN7
      Conserved Domains (3) summary
      pfam00778
      Location:613687
      DIX; DIX domain
      pfam08833
      Location:448497
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. NM_170459.3NP_733338.1  axin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733338.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGN7, Q8IMJ7
      Related
      FBpp0084920
      Conserved Domains (3) summary
      pfam00778
      Location:659733
      DIX; DIX domain
      pfam08833
      Location:494543
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    5. NM_001170302.1NP_001163773.1  axin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ18
      Conserved Domains (2) summary
      cl02565
      Location:55110
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl16934
      Location:1957
      Axin_TNKS_binding; Tankyrase binding N-terminal segment of axin
    6. NM_170458.2NP_733337.1  axin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V407, Q9XYC1
      UniProtKB/TrEMBL
      A4V3M5, C3KGN7
      Related
      FBpp0084921
      Conserved Domains (3) summary
      pfam00778
      Location:665739
      DIX; DIX domain
      pfam08833
      Location:494543
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    7. NM_001276169.1NP_001263098.1  axin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGN7, Q8IMJ7
      Conserved Domains (3) summary
      pfam00778
      Location:659733
      DIX; DIX domain
      pfam08833
      Location:494543
      Axin_b-cat_bind; Axin beta-catenin binding domain
      cl02565
      Location:55170
      RGS; Regulator of G protein signaling (RGS) domain superfamily