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    Erg ETS transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 13876, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ergprovided by MGI
    Official Full Name
    ETS transcription factorprovided by MGI
    Primary source
    MGI:MGI:95415
    See related
    Ensembl:ENSMUSG00000040732 AllianceGenome:MGI:95415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D030036I24Rik
    Summary
    Enables chromatin binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and skeleton. Used to study osteoarthritis. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 16.0), limb E14.5 (RPKM 8.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Erg in Genome Data Viewer
    Location:
    16 C4; 16 56.04 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (95160028..95387452, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (95359169..95586600, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31641 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:95484660-95484843 Neighboring gene predicted gene, 31754 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 15 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95563080-95563380 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95572113-95572413 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95581838-95582139 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95649181-95649482 Neighboring gene STARR-positive B cell enhancer mm9_chr16:95650074-95650374 Neighboring gene STARR-seq mESC enhancer starr_41600 Neighboring gene STARR-seq mESC enhancer starr_41602 Neighboring gene predicted gene, 31845 Neighboring gene predicted gene, 31901

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice. Ng AP, et al. Blood, 2011 Sep 1. PMID 21673349
    2. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Caporarello N, et al. Nat Commun, 2022 Jul 25. PMID 35879310, Free PMC Article
    3. ERG-Mediated Coregulator Complex Formation Maintains Androgen Receptor Signaling in Prostate Cancer. Shah N, et al. Cancer Res, 2020 Nov 1. PMID 32934023
    4. Reduced Erg Dosage Impairs Survival of Hematopoietic Stem and Progenitor Cells. Xie Y, et al. Stem Cells, 2017 Jul. PMID 28436588, Free PMC Article
    5. Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model. Ng AP, et al. PLoS Genet, 2015 May. PMID 25973911, Free PMC Article

    See all (184) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
      Title: ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis.
    2. ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
      Title: ERG mediates the inhibition of NK cell cytotoxicity through the HLX/STAT4/Perforin signaling pathway, thereby promoting the progression of myocardial infarction.
    3. Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
      Title: Oxidative Stress Induces E-Selectin Expression through Repression of Endothelial Transcription Factor ERG.
    4. SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
      Title: SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
    5. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
      Title: Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge.
    6. EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
      Title: EVI1 exerts distinct roles in AML via ERG and cyclin D1 promoting a chemoresistant and immune-suppressive environment.
    7. ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
      Title: ERG Functionally Overlaps with Other Ets Proteins in Promoting TH9 Cell Expression of Il9 during Allergic Lung Inflammation.
    8. ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3beta dependent Nkx3.1 degradation.
      Title: ETS-related gene (ERG) undermines genome stability in mouse prostate progenitors via Gsk3β dependent Nkx3.1 degradation.
    9. EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
      Title: EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer.
    10. Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
      Title: Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (47)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator ERG
    Names
    avian erythroblastosis virus E-26 (v-ets) oncogene related

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302152.1 → NP_001289081.1  transcriptional regulator ERG isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a longer 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79495.1
      UniProtKB/TrEMBL
      B7ZND3, B7ZND4
      Related
      ENSMUSP00000156926.2, ENSMUST00000233269.2
      Conserved Domains (2) summary
      smart00413
      Location:293 → 376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_001302153.1 → NP_001289082.1  transcriptional regulator ERG isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, AK142379, BB639043, BP753340
      Consensus CDS
      CCDS79493.1
      UniProtKB/TrEMBL
      B7ZND3, Q3UQJ4
      Related
      ENSMUSP00000114072.4, ENSMUST00000122199.10
      Conserved Domains (2) summary
      smart00413
      Location:310 → 393
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    3. NM_001302154.1 → NP_001289083.1  transcriptional regulator ERG isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a downstream alternate 5'-terminal exon which reflects use of an alternate promoter supported by epigenetic data, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC154691, AK078113, BB639043, BP753340
      Consensus CDS
      CCDS79492.1
      UniProtKB/TrEMBL
      A0A384DVA0, B7ZND3
      Related
      ENSMUSP00000156927.2, ENSMUST00000233664.2
      Conserved Domains (2) summary
      smart00413
      Location:287 → 370
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    4. NM_001302179.1 → NP_001289108.1  transcriptional regulator ERG isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (5) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79496.1
      UniProtKB/TrEMBL
      B7ZND3
      Related
      ENSMUSP00000109479.5, ENSMUST00000113848.11
      Conserved Domains (2) summary
      smart00413
      Location:294 → 377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    5. NM_001302183.1 → NP_001289112.1  transcriptional regulator ERG isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (6) is shorter compared to isoform 1.
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS79494.1
      UniProtKB/TrEMBL
      B7ZND3, E9PY05
      Related
      ENSMUSP00000132766.2, ENSMUST00000171646.10
      Conserved Domains (2) summary
      smart00413
      Location:270 → 353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    6. NM_133659.3 → NP_598420.1  transcriptional regulator ERG isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154691, AK050922, AK078113, BP753340
      Consensus CDS
      CCDS37411.1
      UniProtKB/Swiss-Prot
      A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
      UniProtKB/TrEMBL
      B7ZND3
      Related
      ENSMUSP00000156669.2, ENSMUST00000233881.2
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      95160028..95387452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522895.3 → XP_006522958.1  transcriptional regulator ERG isoform X2

      UniProtKB/Swiss-Prot
      A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    2. XM_006522903.3 → XP_006522966.1  transcriptional regulator ERG isoform X6

      UniProtKB/TrEMBL
      B7ZND3, E9PY05
      Conserved Domains (2) summary
      smart00413
      Location:270 → 353
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    3. XM_006522900.3 → XP_006522963.1  transcriptional regulator ERG isoform X4

      UniProtKB/TrEMBL
      B7ZND3, B7ZND4
      Conserved Domains (2) summary
      smart00413
      Location:293 → 376
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    4. XM_006522899.3 → XP_006522962.1  transcriptional regulator ERG isoform X3

      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:294 → 377
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    5. XM_006522894.3 → XP_006522957.1  transcriptional regulator ERG isoform X2

      UniProtKB/Swiss-Prot
      A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    6. XM_006522896.5 → XP_006522959.1  transcriptional regulator ERG isoform X2

      UniProtKB/Swiss-Prot
      A6H6E7, P81270, Q8C5L4, Q920K7, Q920K8, Q920K9
      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:317 → 400
      ETS; erythroblast transformation specific domain
      cl15755
      Location:122 → 205
      SAM_superfamily; SAM (Sterile alpha motif )

    7. XM_030248973.2 → XP_030104833.1  transcriptional regulator ERG isoform X7

      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:263 → 346
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    8. XM_030248972.2 → XP_030104832.1  transcriptional regulator ERG isoform X5

      UniProtKB/TrEMBL
      B7ZND3, I1E4Y2
      Related
      ENSMUSP00000113723.5, ENSMUST00000121809.11
      Conserved Domains (2) summary
      smart00413
      Location:286 → 369
      ETS; erythroblast transformation specific domain
      cl15755
      Location:115 → 198
      SAM_superfamily; SAM (Sterile alpha motif )

    9. XM_006522904.5 → XP_006522967.1  transcriptional regulator ERG isoform X8

      UniProtKB/TrEMBL
      H3BKX4
      Related
      ENSMUSP00000135568.4, ENSMUST00000176345.10
      Conserved Domains (2) summary
      smart00413
      Location:278 → 361
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83 → 166
      SAM_superfamily; SAM (Sterile alpha motif )

    10. XM_036159777.1 → XP_036015670.1  transcriptional regulator ERG isoform X1

      UniProtKB/TrEMBL
      B7ZND3
      Conserved Domains (2) summary
      smart00413
      Location:212 → 295
      ETS; erythroblast transformation specific domain
      cl15755
      Location:83 → 166
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P81270.2 GenPept UniProtKB/Swiss-Prot:P81270

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