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    CDD1 cytidine deaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDD1
    Official Full Name
    cytidine deaminase
    Primary source
    SGD:S000004235
    Locus tag
    YLR245C
    See related
    AllianceGenome:SGD:S000004235; FungiDB:YLR245C; VEuPathDB:YLR245C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cytidine deaminase activity. Involved in cytidine catabolic process; deoxycytidine catabolic process; and pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CDA (cytidine deaminase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDD1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (626502..626930, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative signal sequence-binding GTPase GPN3 Neighboring gene methionine aminopeptidase MAP1 Neighboring gene palmitoyltransferase ERF2 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of a Schizosaccharomyces pombe gene which in high copy confers resistance to the nucleoside analogue 5-azacytidine. Platt GM, et al. Yeast, 1997 Apr. PMID 9153756
    2. Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. Dance GS, et al. Nucleic Acids Res, 2001 Apr 15. PMID 11292850, Free PMC Article
    3. The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1. Xie K, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15148397, Free PMC Article
    4. New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Kurtz JE, et al. Curr Genet, 1999 Sep. PMID 10501935
    5. Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase. Guo X, et al. J Biol Chem, 2017 Jul 14. PMID 28539364, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytidine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate derivative metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytidine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytidine deamination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deoxycytidine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleobase-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine-containing compound salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytidine deaminase
    NP_013346.1
    • Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      626502..626930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182132.1 → NP_013346.1  TPA: cytidine deaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYP3, Q06549
      UniProtKB/TrEMBL
      A7A1C8, B3RHD0, C7GQZ1, C8ZDK8, G2WJ71, N1P6X7
      Conserved Domains (1) summary
      TIGR01354
      Location:12 → 141
      cyt_deam_tetra; cytidine deaminase, homotetrameric
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06549.1

    Gene LinkOut

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