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    RFU1 Rfu1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFU1
    Official Full Name
    Rfu1p
    Primary source
    SGD:S000004063
    Locus tag
    YLR073C
    See related
    AllianceGenome:SGD:S000004063; FungiDB:YLR073C; VEuPathDB:YLR073C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme inhibitor activity. Involved in ubiquitin recycling. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFU1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (281019..281621, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rgr1p Neighboring gene Lam6p Neighboring gene Bud20p Neighboring gene ribosomal 60S subunit protein L10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis. Kimura Y, et al. J Biol Chem, 2014 Aug 1. PMID 24962567, Free PMC Article
    2. Conserved Mode of Interaction between Yeast Bro1 Family V Domains and YP(X)nL Motif-Containing Target Proteins. Kimura Y, et al. Eukaryot Cell, 2015 Oct. PMID 26150415, Free PMC Article
    3. An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis. Kimura Y, et al. Cell, 2009 May 1. PMID 19410548
    4. Whi3, a developmental regulator of budding yeast, binds a large set of mRNAs functionally related to the endoplasmic reticulum. Colomina N, et al. J Biol Chem, 2008 Oct 17. PMID 18667435, Free PMC Article
    5. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Aguilar PS, et al. Nat Struct Mol Biol, 2010 Jul. PMID 20526336, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of Bro1, particularly the V domain, prevented Rfu1 degradation in response to heat shock
      Title: The ESCRT-III adaptor protein Bro1 controls functions of regulator for free ubiquitin chains 1 (Rfu1) in ubiquitin homeostasis.
    2. identified a protein designated Rfu1 (regulator of free ubiquitin chains 1), which regulates intracellular concentrations of monomeric ubiquitins; functions as an inhibitor of Doa4
      Title: An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ubiquitin recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome HDA PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rfu1p
    NP_013174.1
    • Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      281019..281621 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181960.1 → NP_013174.1  TPA: Rfu1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013174.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7A0X8, B3LT42, D6VY74, Q08003
      UniProtKB/TrEMBL
      C7GQP8, C8ZD44, G2WIR5, N1NY30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08003.1

    Gene LinkOut

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