UGP1 UTP glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: UGP1
Official Full Name: UTP glucose-1-phosphate uridylyltransferase
Primary source: SGD:S000001518
Locus tag: YKL035W
See related: AllianceGenome:SGD:S000001518; FungiDB:YKL035W; VEuPathDB:YKL035W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process; glucan biosynthetic process; and trehalose biosynthetic process. Located in cytoplasmic stress granule and plasma membrane. Used to study cancer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See UGP1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (369891..371390)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In sum, high-copy ISR1 and UGP1 cells affect early steps of the zymocin response and potentially prevent the lethal K. lactis killer complex from establishing cell surface recognition and/or contact.
Title: Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1.
crystal structure of Ugp1, its subunits, binding sites, and octameric complex, and implications of this oligomeric arrangement for regulation of UGPase activity
Title: Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae.
Yeast PAS kinases phosphorylate this enyme, the primary producer of UDP-glucose and the glucose donor for glucan biosynthesis.
Title: Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables UTP:glucose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UTP:glucose-1-phosphate uridylyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-alpha-D-glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in UDP-alpha-D-glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-alpha-D-glucose metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in UDP-alpha-D-glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: UTP glucose-1-phosphate uridylyltransferase

NP_012889.3

EC 2.7.7.9

UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

369891..371390

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179601.3 → NP_012889.3 TPA: UTP glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012889.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXQ0, P32861

UniProtKB/TrEMBL

A6ZZS9, B3LR51, B5VMB9, C7GP37, C8ZCD4, G2WHZ5, N1P7W9

Conserved Domains (1) summary

pfam01704
Location:52 → 464

UDPGP; UTP--glucose-1-phosphate uridylyltransferase