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    HIS5 histidinol-phosphate transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HIS5
    Official Full Name
    histidinol-phosphate transaminase
    Primary source
    SGD:S000001378
    Locus tag
    YIL116W
    See related
    AllianceGenome:SGD:S000001378; FungiDB:YIL116W; VEuPathDB:YIL116W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histidinol-phosphate transaminase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HIS5 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (142928..144085)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rho family GTPase RHO3 Neighboring gene pheromone-regulated protein PRM5 Neighboring gene FG-nucleoporin NUP159 Neighboring gene putative porin POR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the yeast HIS5 gene responsive to general control of amino acid biosynthesis. Nishiwaki K, et al. Mol Gen Genet, 1987 Jun. PMID 3302607
    2. Cloning of the HIS5 gene of Saccharomyces cerevisiae by yeast transformation. Harashima S, et al. Gene, 1981 Dec. PMID 7044894
    3. GENE-ENZYME RELATIONS IN HISTIDINE BIOSYNTHESIS IN YEAST. FINK GR. Science, 1964 Oct 23. PMID 14190241
    4. Toxicity of copper, cobalt, and nickel salts is dependent on histidine metabolism in the yeast Saccharomyces cerevisiae. Pearce DA, et al. J Bacteriol, 1999 Aug. PMID 10438744, Free PMC Article
    5. Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae. He C, et al. J Proteome Res, 2018 Jul 6. PMID 29897761

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histidinol-phosphate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidinol-phosphate transaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    histidinol-phosphate transaminase
    NP_012150.1
    • Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      142928..144085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179464.1 → NP_012150.1  TPA: histidinol-phosphate transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012150.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH1, P07172
      UniProtKB/TrEMBL
      A6ZVG1, B3LTW3, B5VKJ3, C8ZAC8, G2WG35, N1P1X8
      Conserved Domains (1) summary
      TIGR01141
      Location:10 → 377
      hisC; histidinol-phosphate aminotransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07172.2

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