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    SNG1 Sng1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SNG1
    Official Full Name
    Sng1p
    Primary source
    SGD:S000003429
    Locus tag
    YGR197C
    See related
    AllianceGenome:SGD:S000003429; FungiDB:YGR197C; VEuPathDB:YGR197C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nucleobase-containing compound transport; regulation of fungal-type cell wall organization; and regulation of phospholipid translocation. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SNG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (892497..894140, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit SKI6 Neighboring gene Fyv8p Neighboring gene Ypp1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNG1--a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae. Grey M, et al. Mutat Res, 1995 Apr. PMID 7753113
    2. Genome-wide screening of Saccharomyces cerevisiae genes regulated by vanillin. Park EH, et al. J Microbiol Biotechnol, 2015 Jan. PMID 25269814
    3. Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae. García-López MC, et al. Curr Genet, 2010 Jun. PMID 20424846
    4. Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status. García-Marqués S, et al. Biochim Biophys Acta, 2016 Jun. PMID 27033517
    5. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system. Le Crom S, et al. Mol Cell Biol, 2002 Apr. PMID 11909958, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that mutant nce102 sng1 cells show features of impaired Pkh/Ypk signalling, including increased reactive oxygen species accumulation.
      Title: Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status.
    2. They have identified SNG1 as a multicopy suppressor of the 6AU(S) growth defect caused by the S. cerevisiae rpb1 mutant.
      Title: Overexpression of SNG1 causes 6-azauracil resistance in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of phospholipid translocation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sng1p
    NP_011713.1
    • Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      892497..894140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181326.1 → NP_011713.1  TPA: Sng1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUX9, P46950
      UniProtKB/TrEMBL
      A6ZUK7, B3LI40, N1P2I3
      Conserved Domains (1) summary
      pfam12051
      Location:112 → 497
      DUF3533; Protein of unknown function (DUF3533)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46950.1

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