HAT2 Hat2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HAT2
Official Full Name: Hat2p
Primary source: SGD:S000000782
Locus tag: YEL056W
See related: AllianceGenome:SGD:S000000782; FungiDB:YEL056W; VEuPathDB:YEL056W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables histone binding activity. Contributes to histone acetyltransferase activity. Involved in subtelomeric heterochromatin formation. Located in cytoplasm and nucleus. Part of histone acetyltransferase complex. Orthologous to human RBBP4 (RB binding protein 4, chromatin remodeling factor) and RBBP7 (RB binding protein 7, chromatin remodeling factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HAT2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (47168..48373)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3 N-terminal peptides can bind to the Hat2p WD40 domain
Title: Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex.
The participation of a distinct Hat1p/Hat2p sub-complex suggests a linkage of histone H4 modification with ORC-dependent DNA replication
Title: Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to histone acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Rpd3L complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rpd3L-Expanded complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of histone acetyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hat2p

NP_010858.3

Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

47168..48373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178871.3 → NP_010858.3 TPA: Hat2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010858.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLJ4, P39984

UniProtKB/TrEMBL

A6ZQP5, B3LRW2, B5VH80, C7GXE3, G2WCH8, N1P3J0

Conserved Domains (3) summary

COG2319
Location:116 → 401

WD40; WD40 repeat [General function prediction only]

sd00039
Location:122 → 158

7WD40; WD40 repeat [structural motif]

pfam12265
Location:12 → 82

CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex