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    PDS1 securin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PDS1
    Official Full Name
    securin
    Primary source
    SGD:S000002520
    Locus tag
    YDR113C
    See related
    AllianceGenome:SGD:S000002520; FungiDB:YDR113C; VEuPathDB:YDR113C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables enzyme binding activity. Involved in several processes, including negative regulation of exit from mitosis; nuclear division; and recombinational repair. Located in cytoplasm; nucleus; and spindle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PDS1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (680496..681617, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene replication fork barrier binding protein FOB1 Neighboring gene alanine transaminase ALT2 Neighboring gene uncharacterized protein Neighboring gene putative mitochondrial 54S ribosomal protein Neighboring gene mitochondrial 54S ribosomal protein MRPL1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. Yamamoto A, et al. J Cell Biol, 1996 Apr. PMID 8601616, Free PMC Article
    2. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Cohen-Fix O, et al. Genes Dev, 1996 Dec 15. PMID 8985178
    3. Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast. Salah SM, et al. Chromosoma, 2000. PMID 10855492
    4. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: evidence that proper spindle association of Esp1 is regulated by Pds1. Jensen S, et al. J Cell Biol, 2001 Jan 8. PMID 11149918, Free PMC Article
    5. Pds1 phosphorylation in response to DNA damage is essential for its DNA damage checkpoint function. Wang H, et al. Genes Dev, 2001 Jun 1. PMID 11390356, Free PMC Article

    See all (163) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling.
      Title: Dun1, a Chk2-related kinase, is the central regulator of securin-separase dynamics during DNA damage signaling.
    2. Here, we show that Rts1 is required for the proportional relationship between cell size and growth rate during mitosis. Moreover, nutrients and Rts1 influence the duration and extent of growth in mitosis via Wee1 and Pds1/securin, two conserved regulators of mitotic progression.
      Title: A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.
    3. crystal structures at up to 2.6 A resolution of the yeast Saccharomyces cerevisiae separase-securin complex
      Title: Molecular mechanism for the regulation of yeast separase by securin.
    4. These data indicate that Clb5 and Clb6 promote cohesion which is then protected by Pds1 and that both mechanisms are required during replication stress.
      Title: S-phase cyclin-dependent kinases promote sister chromatid cohesion in budding yeast.
    5. These results define a previously undescribed role for Pds1p in cohesin maintenance, recombination, and meiotic progression.
      Title: Pds1p is required for meiotic recombination and prophase I progression in Saccharomyces cerevisiae.
    6. RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
      Title: The Saccharomyces cerevisiae checkpoint genes RAD9, CHK1 and PDS1 are required for elevated homologous recombination in a mec1 (ATR) hypomorphic mutant.
    7. phosphorylation of Pds1 but not Rad53 correlates with G2 arrest in response to double-strand breaks in the mec1 hypomorphic mutant
      Title: Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant.
    8. protein phosphatase 2A regulates sister chromatid cohesion in Pds1-dependent and -independent manners
      Title: Pds1/Esp1-dependent and -independent sister chromatid separation in mutants defective for protein phosphatase 2A.
    9. Chk1-Pds1 checkpoint has roles in preventing tolerance of persistent single-strand breaks in Saccharomyces cerevisiae
      Title: Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in recombinational repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in recombinational repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    securin
    NP_010398.3
    • Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      680496..681617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180421.3 → NP_010398.3  TPA: securin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010398.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS98, P40316
      UniProtKB/TrEMBL
      N1P874
      Conserved Domains (1) summary
      pfam04856
      Location:9 → 356
      Securin; Securin sister-chromatid separation inhibitor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40316.1

    Gene LinkOut

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